Antineoplastics
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Reactions 1173 - 13 Oct 2007 S Antineoplastics Oesophageal stricture in a child with Candida pericarditis: case report A 3-year-old girl with Candida pericarditis developed oesophagus stricture during treatment with vincristine, doxorubicin, prednisolone and methotrexate for pre-B acute lymphoblastic leukaemia [dosage and duration of treatment to reaction onset not stated]. The girl was hospitalised on 6 November and received her first antineoplastic treatment of vincristine, doxorubicin, prednisolone and intrathecal injections of methotrexate. Five days after treatment initiation, she had Candida in her genital area and on her skin and tongue. Despite administration of various antibacterials and antifungals, she developed Candida pericarditis, which was treated with voriconazole. On 15 December, she was improving. Subsequently, she developed progressive dysphagia and was unable to eat or swallow her own saliva; she was still receiving voriconazole. Barium oesophagography revealed a 6cm long stricture in her distal oesophagus. On 25 April 2006, IV voriconazole was replaced by oral therapy. [Patient outcome not stated.] Author comment: "It is speculated that the chemotherapeutic induced mucosa lesion in the eosophagus plus candida affection lead to a severe eosophageal stricture." Dahl C, et al. A paediatric case of Candida pericarditis and eosophagus stricture during treatment for acute lymphatic leukaemia. Acta Oncologica 46: 859-861, No. 6, 2007 - Denmark 801091769 1 Reactions 13 Oct 2007 No. 1173 0114-9954/10/1173-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1173 - 13 Oct 2007
SAntineoplastics
Oesophageal stricture in a child with Candidapericarditis: case report
A 3-year-old girl with Candida pericarditis developedoesophagus stricture during treatment with vincristine,doxorubicin, prednisolone and methotrexate for pre-B acutelymphoblastic leukaemia [dosage and duration of treatment toreaction onset not stated].
The girl was hospitalised on 6 November and received herfirst antineoplastic treatment of vincristine, doxorubicin,prednisolone and intrathecal injections of methotrexate. Fivedays after treatment initiation, she had Candida in her genitalarea and on her skin and tongue. Despite administration ofvarious antibacterials and antifungals, she developed Candidapericarditis, which was treated with voriconazole. On15 December, she was improving. Subsequently, shedeveloped progressive dysphagia and was unable to eat orswallow her own saliva; she was still receiving voriconazole.Barium oesophagography revealed a 6cm long stricture in herdistal oesophagus. On 25 April 2006, IV voriconazole wasreplaced by oral therapy. [Patient outcome not stated.]
Author comment: "It is speculated that thechemotherapeutic induced mucosa lesion in the eosophagusplus candida affection lead to a severe eosophageal stricture."Dahl C, et al. A paediatric case of Candida pericarditis and eosophagus strictureduring treatment for acute lymphatic leukaemia. Acta Oncologica 46: 859-861, No.6, 2007 - Denmark 801091769
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Reactions 13 Oct 2007 No. 11730114-9954/10/1173-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
