Antineoplastics
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Reactions 1083 - 7 Jan 2006 S Antineoplastics Fatal human polyomavirus pneumonia in an elderly patient: case report A 69-year-old woman developed fatal human polyomavirus pneumonia after long-term antineoplastic therapy for chronic lymphocytic leukaemia (CLL). The woman had a 20-year history of CLL and had received numerous cycles of radiation therapy and antineoplastic therapy [drugs and dosages not stated]. As a result of this treatment, she was immunocompromised. She had a history of chronic obstructive pulmonary disease and several hospitalisations for pneumonia. During her final admission, her lung function worsened progressively despite treatment with antibacterials and corticosteroids, and she died 73 days after her first admission for pneumonia. Subsequent histology revealed an extensive pattern of diffuse alveolar damage with interstitial pneumonitis. Large intranuclear basophilic viral inclusions were observed and identified as human polyomavirus. Galan A, et al. Fatal BK polyoma viral pneumonia associated with immunosuppression. Human Pathology 36: 1031-1034, No. 9, Sep 2005 - USA 800986786 1 Reactions 7 Jan 2006 No. 1083 0114-9954/10/1083-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1083 - 7 Jan 2006
SAntineoplastics
Fatal human polyomavirus pneumonia in an elderlypatient: case report
A 69-year-old woman developed fatal human polyomaviruspneumonia after long-term antineoplastic therapy for chroniclymphocytic leukaemia (CLL).
The woman had a 20-year history of CLL and had receivednumerous cycles of radiation therapy and antineoplastictherapy [drugs and dosages not stated]. As a result of thistreatment, she was immunocompromised. She had a history ofchronic obstructive pulmonary disease and severalhospitalisations for pneumonia. During her final admission,her lung function worsened progressively despite treatmentwith antibacterials and corticosteroids, and she died 73 daysafter her first admission for pneumonia. Subsequent histologyrevealed an extensive pattern of diffuse alveolar damage withinterstitial pneumonitis. Large intranuclear basophilic viralinclusions were observed and identified as humanpolyomavirus.Galan A, et al. Fatal BK polyoma viral pneumonia associated withimmunosuppression. Human Pathology 36: 1031-1034, No. 9, Sep 2005 -USA 800986786
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Reactions 7 Jan 2006 No. 10830114-9954/10/1083-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
