Antineoplastics
1
Reactions 908 - 29 Jun 2002 ★ S Antineoplastics First report of fatal gallbladder carcinoma in an elderly patient: case report A 67-year-old man developed carcinoma of the gallbladder after repetitive hepatic arterial chemoembolisation for the treatment of hepatocellular carcinoma. The man had received 9 courses of hepatic arterial chemoembolisation [drug and dosage not stated] over a 3-year period when he presented with a 15-day history of progressive jaundice and fever. He had a history of alcohol-related cirrhosis and hepatocellular carcinoma in the right lobe of his liver with atrophy of his left lobe. A cholangiogram revealed lesions of secondary sclerosing cholangitis. Placement of an endoscopic stent was carried out and was partially effective. He then underwent a surgical procedure which involved hepaticojejunal anastomosis with cholescystectomy. Pathological examination found transmural fibrosis, thickening and replacement of the man’s gallbladder wall with granulation tissue. There was adenocarcinoma infiltration of the serosa in his gallbladder. He died a few days later from septic shock. Author comment: ‘Our case report provides evidence for a direct link between chronic acalculous cholecystitis and cancer . . . Cholecystectomy has to be discussed in patients treated with repetitive courses of HACE [hepatic arterial chemoembolisation].’ Balian A, et al. Gallbladder carcinoma secondary to repetitive hepatic arterial chemoembolization. American Journal of Gastroenterology 97: 1079-1080, Apr 2002 - France 800908019 » Editorial comment: A search of AdisBase and Medline did not reveal any previous case reports of gallbladder carcinoma associated with antineoplastic agents. The WHO Adverse Drug Reactions database contained 2 reports of bile duct carcinoma associated with the antineoplastic agent fluorouracil. 1 Reactions 29 Jun 2002 No. 908 0114-9954/10/0908-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 908 - 29 Jun 2002
★ SAntineoplastics
First report of fatal gallbladder carcinoma in anelderly patient: case report
A 67-year-old man developed carcinoma of the gallbladderafter repetitive hepatic arterial chemoembolisation for thetreatment of hepatocellular carcinoma.
The man had received 9 courses of hepatic arterialchemoembolisation [drug and dosage not stated] over a 3-yearperiod when he presented with a 15-day history of progressivejaundice and fever. He had a history of alcohol-relatedcirrhosis and hepatocellular carcinoma in the right lobe of hisliver with atrophy of his left lobe. A cholangiogram revealedlesions of secondary sclerosing cholangitis. Placement of anendoscopic stent was carried out and was partially effective.He then underwent a surgical procedure which involvedhepaticojejunal anastomosis with cholescystectomy.
Pathological examination found transmural fibrosis,thickening and replacement of the man’s gallbladder wall withgranulation tissue. There was adenocarcinoma infiltration ofthe serosa in his gallbladder. He died a few days later fromseptic shock.
Author comment: ‘Our case report provides evidence for adirect link between chronic acalculous cholecystitis and cancer. . . Cholecystectomy has to be discussed in patients treatedwith repetitive courses of HACE [hepatic arterialchemoembolisation].’Balian A, et al. Gallbladder carcinoma secondary to repetitive hepatic arterialchemoembolization. American Journal of Gastroenterology 97: 1079-1080, Apr2002 - France 800908019
» Editorial comment: A search of AdisBase and Medline didnot reveal any previous case reports of gallbladder carcinomaassociated with antineoplastic agents. The WHO Adverse DrugReactions database contained 2 reports of bile duct carcinomaassociated with the antineoplastic agent fluorouracil.
1
Reactions 29 Jun 2002 No. 9080114-9954/10/0908-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
