Antineoplastics
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Reactions 1478, p8 - 16 Nov 2013 Antineoplastics Skin rash in a child: case report An 8-year-old boy developed a skin rash during treatment with the antineoplastics gemcitabine, ifosfamide, prednisolone and vinorelbine. The boy had Hodgkin’s disease. He had been treated with bleomycin, dacarbazine, doxorubicin and vinblastine. Due to progressive disease, he started receiving chemotherapy with gemcitabine, vinorelbine, ifosfamide and prednisolone. In each 21-day cycle, he was scheduled to receive gemcitabine 800 mg/m 2 on days 1–4, ifosfamide 2000 mg/m 2 on days 1–4, prednisolone 2 mg/kg on days 1–4 and vinorelbine 20 mg/m 2 on day 1 [routes not stated]. On day 3 of treatment, he exhibited a skin rash that was maculopapular and pruritic. He had rashes that affected his chest, neck, back, abdominal wall and upper arms. The boy was treated with an antihistamine, and the rashes decreased in severity. During the second cycle of chemotherapy, he received gemcitabine again. The rashes reappeared. They were managed easily again with antihistamines. Author comment: "The other drugs being used in this child also cause skin rash and the possibility of this reaction due to them, or additive effect of all the drugs cannot be ruled out. . . The causal relationship of gemcitabine treatment with skin reaction is probable in our case according to the Naranjo probability scale." Dua V, et al. Gemcitabine induced skin rash. Indian Pediatrics 50: 430, No. 4, 16 Apr 2013. Available from: URL: http://dx.doi.org/10.1007/s13312-013-0109-x - India 803095698 » Editorial comment: Details of this case report have previously been published [see Reactions 1439 p18; 803082950] as an abstract. 1 Reactions 16 Nov 2013 No. 1478 0114-9954/13/1478-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
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Transcript of Antineoplastics
Reactions 1478, p8 - 16 Nov 2013
Antineoplastics
Skin rash in a child: case reportAn 8-year-old boy developed a skin rash during treatment
with the antineoplastics gemcitabine, ifosfamide, prednisoloneand vinorelbine.
The boy had Hodgkin’s disease. He had been treated withbleomycin, dacarbazine, doxorubicin and vinblastine. Due toprogressive disease, he started receiving chemotherapy withgemcitabine, vinorelbine, ifosfamide and prednisolone. Ineach 21-day cycle, he was scheduled to receive gemcitabine800 mg/m2 on days 1–4, ifosfamide 2000 mg/m2 on days 1–4,prednisolone 2 mg/kg on days 1–4 and vinorelbine 20 mg/m2
on day 1 [routes not stated]. On day 3 of treatment, heexhibited a skin rash that was maculopapular and pruritic. Hehad rashes that affected his chest, neck, back, abdominal walland upper arms.
The boy was treated with an antihistamine, and the rashesdecreased in severity. During the second cycle ofchemotherapy, he received gemcitabine again. The rashesreappeared. They were managed easily again withantihistamines.
Author comment: "The other drugs being used in thischild also cause skin rash and the possibility of this reactiondue to them, or additive effect of all the drugs cannot beruled out. . . The causal relationship of gemcitabine treatmentwith skin reaction is probable in our case according to theNaranjo probability scale."Dua V, et al. Gemcitabine induced skin rash. Indian Pediatrics 50: 430, No. 4, 16Apr 2013. Available from: URL: http://dx.doi.org/10.1007/s13312-013-0109-x -India 803095698
» Editorial comment: Details of this case report havepreviously been published [see Reactions 1439 p18;803082950] as an abstract.
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Reactions 16 Nov 2013 No. 14780114-9954/13/1478-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
