Reactions 1428 - 17 Nov 2012

SAntineoplastics

Gastrointestinal upset and myocardial injuries:case report

A 62-year-old woman developed gastrointestinal upsetand myocardial injuries during treatment withantineoplastics [routes not stated].

The woman had been diagnosed initially with gastricantral cancer. Later, she was diagnosed with light-chain(AL) amyloidosis with gastrointestinal and skininvolvement. After the discovery of marrow plasmacytosis,it was concluded that she had multiple myeloma associatedwith AL amyloidosis. After the diagnosis of multiplemyeloma, she was started on a chemotherapy regimenwith cyclophosphamide, vindesine, pirarubicin anddexamethasone. On the first day, she was scheduled toreceive cyclophosphamide 800mg and vindesine 3mg. Ondays 1 and 2, she was scheduled to receive pirarubicin20 mg/day. On days 1 to 5, she was to receivedexamethasone 20 mg/day.

The woman developed myocardial injuries andgastrointestinal upset due to antineoplastic toxicity[duration of treatment to reaction onset not clearly stated].She developed cardiorespiratory arrest on the third day ofchemotherapy and also developed grave metabolicacidosis. Her renal and hepatic functions declined as well.She died from multiple organ failure.

Author comment: "Unfortunately, because ofchemotherapeutic toxicity, the patient suffered from seriousgastrointestinal upset and myocardial injuries."Liu W, et al. Multiple myeloma associated with light-chain amyloidosismanifesting as gastric retention: A case report and review of the literature. WestIndian Medical Journal 60: 681-684, No. 6, Dec 2011 - China 803079854

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Reactions 17 Nov 2012 No. 14280114-9954/10/1428-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved