Reactions 1367 - 3 Sep 2011

SAntineoplastics

Skin sensitisation: case reportA 49-year-old woman, who had cutaneous Langerhans

cell histiocytosis, started receiving methotrexate [route anddosage not stated] and then vinblastine [route and dosagenot stated]. Her chemotherapy was subsequently switchedto fludarabine, cyclophosphamide, cladribine, andvinblastine [routes and dosages not stated]. Duringtreatment, she developed neutropenia and peripheralneuropathy. Her chemotherapy was stopped due to lack ofresponse, and she started receiving radiotherapy. Duringradiotherapy, she experienced worsening skin breakdown[time to reaction onset not stated]. Addtionally, her painworsened toward the end of the treatment, which requiredan increase in her opiate requirements. Six months later,her wounds fully healed.

Author comment: "It is well established that prior orconcurrent chemotherapy can significantly increase skintoxicity and such a chemotherapy-induced sensitization is apossibility in our case as well."Hristov B, et al. Chemotherapy-refractory cutaneous Langerhans cell histiocytosistreated with radiotherapy. Practical Radiation Oncology 1: 204-207, No. 3, Sep2011. Available from: URL: http://dx.doi.org/10.1016/j.prro.2010.12.001 -USA 803059553

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Reactions 3 Sep 2011 No. 13670114-9954/10/1367-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved