Reactions 1321 - 2 Oct 2010

SOxcarbazepine

Hepatitis: case reportAn 8-year-old girl started receiving oxcarbazepine twice

daily, 10 mg/kg/day [route not stated] for partial epilepsies.Fourteen days later, she presented with a 2-day history ofmalaise and poor appetite and a 1-day history of fever. Onadmission it was noted that she had acute hepatitis withpharyngitis. She received supportive care and IV fluids.Oxcarbazepine was withdrawn and she started receivinglevetiracetam. On day 4 of hospitalisation, her liverenzymes had improved and her symptoms had resolved.She was discharged in a stable condition.

Author comment: "We conclude that oxcarbazepine wasdirectly responsible for the present patient’s liver functionimpairment."Hsu H-F, et al. Severe hepatitis associated with administration of oxcarbazepine.Pediatrics International 52: 677-678, Aug 2010. Available from: URL: http://dx.doi.org/10.1111/j.1442-200x.2010.03154.x - Taiwan 803040571

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Reactions 2 Oct 2010 No. 13210114-9954/10/1321-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved