Reactions 1096 - 8 Apr 2006

Carbamazepine

Lupus erythematosus: case reportA 35-year-old man, who had received carbamazepine

[dosage not stated] for 20 years for epilepsy, complained ofchest pain, dyspnoea and reduced physical activity for3 months [duration of treatment before reaction onset notclearly stated]. After he was subsequently diagnosed with alarge pericardial effusion and had undergonepericardiocentesis (1200mL), viral perimyocarditis wassuspected. He received anti-inflammatory treatment and hissymptoms initially resolved. After 4 weeks, his pericardialeffusion recurred and livedo reticularis was evident.Serological examination showed antinuclear antibodies andantibodies against histones. He was diagnosed withcarbamazepine-induced lupus erythematosus. Aftercarbamazepine discontinuation and immunosuppressivetherapy initiation, he recovered completely.Wittchen F, et al. Chest pain, reduced physical activity and polyserositis in a35-year old patient with anticonvulsive medication. Internist 47: 69-74, No. 1, Jan2006 [German; summarised from an English abstract] - Germany 801036909

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Reactions 8 Apr 2006 No. 10960114-9954/10/1096-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved