Prof. Stefan Linder. Stefan Linder UKE Hamburg, Institut für medizinische Mikrobiologie, Virologie...
1
SFB877-Sprecher : Prof. Dr. Stefan Rose-John Biochemisches Institut, Olshausenstrasse 40, D-24118 Kiel, Tel. 0431 880 -3336 /-2018 http://www.uni-kiel.de/Biochemie/sfb877 Prof. Stefan Linder UKE Hamburg, Institut für medizinische Mikrobiologie, Virologie und Hygiene ` Novel regulators and functions of metalloproteinase MT1-MMP in primary macrophages ´ The matrix metalloproteinase MT1-MMP is a key regulator of proteolytic cell invasion in both health and disease. MT1-MMP is membrane-bound and cleaves extracellular matrix components, matrix receptors and also intracellular target proteins. Moreover, it is able to proteolytically activate other members of the MMP family and is thus recognized as a “master switch” proteinase. This talk will address the molecular mechanisms that regulate intracellular trafficking of MT1-MMP in primary human macrophages, including exposure on and recycling from the cell surface. A particular focus will be on the role of kinesin motor proteins and vesicle regulators of the RabGTPase family, and also on an unexpected structural role of MT1-MMP as a cellular memory device. The talk will also examine the impact of these newly identified regulators on macrophage invasion and cancer cell co-invasion in 3D models. Sonderforschungsbereich 877 an der Christian-Albrechts-Universität zu Kiel Proteolysis as a Regulatory Event in Pathophysiology SFB877 Seminar Dienstag 23. Mai 2017 17:15 Uhr Hörsaal, CAU Kiel Rudolf-Höber-Str. 1
Transcript of Prof. Stefan Linder. Stefan Linder UKE Hamburg, Institut für medizinische Mikrobiologie, Virologie...
SFB877-Sprecher: Prof. Dr. Stefan Rose-John
Biochemisches Institut, Olshausenstrasse 40, D-24118 Kiel, Tel. 0431 880 -3336 /-2018 http://www.uni-kiel.de/Biochemie/sfb877
Prof. Stefan Linder UKE Hamburg, Institut für medizinische Mikrobiologie, Virologie und Hygiene
`Novel regulators and functions of metalloproteinase
MT1-MMP in primary macrophages´ The matrix metalloproteinase MT1-MMP is a key regulator of proteolytic cell invasion in both health and disease. MT1-MMP is membrane-bound and cleaves extracellular matrix components, matrix receptors and also intracellular target proteins. Moreover, it is able to proteolytically activate other members of the MMP family and is thus recognized as a “master switch” proteinase. This talk will address the molecular mechanisms that regulate intracellular trafficking of MT1-MMP in primary human macrophages, including exposure on and recycling from the cell surface. A particular focus will be on the role of kinesin motor proteins and vesicle regulators of the RabGTPase family, and also on an unexpected structural role of MT1-MMP as a cellular memory device. The talk will also examine the impact of these newly identified regulators on macrophage invasion and cancer cell co-invasion in 3D models.
Sonderforschungsbereich 877
an der Christian-Albrechts-Universität zu Kiel
Proteolysis as a Regulatory Event
in Pathophysiology
SFB877 Seminar
Dienstag
23. Mai 2017
17:15 Uhr
Hörsaal, CAU Kiel
Rudolf-Höber-Str. 1
