Oxcarbazepine
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Reactions 1412 - 28 Jul 2012 S Oxcarbazepine Myoclonic seizures in an infant with generalised tonic-clonic seizures: case report A 1-year-old female infant developed myoclonic seizures during treatment with oxcarbazepine for generalised tonic- clonic seizures (GTCS). The girl, who had no family history of seizures or epilepsy, had her first GTCS at age 6 months; the seizures lasted for 1–3 minutes at a frequency of 1–3 times a day. CT of the head was normal and an EEG showed no interictal epileptiform activity. She began receiving an oral suspension of oxcarbazepine [initial dosage not stated] which was titrated up to 22 mg/kg/d. Over the following 20 days, she had no further seizures. Then she began experiencing clusters of head drops with occasionally bilateral myoclonic movement [duration of treatment to reaction onset not clearly stated]. An EEG revealed generalised poly-spike and poly-spike-slow waves. The girl’s oxcarbazepine was tapered off and then stopped in 3 days. She began receiving valproate and she had no further seizures were observed 1 week later. Her EEG gradually normalised over the following 2 months and her subsequent development was age-appropriate. Author comment: "Although the child was not rechallenged with [oxcarbazepine], it seems likely that her antiepileptic drug regimen did play a role in the myoclonic seizures." Deng S, et al. Myoclonus precipitated by oral suspension of oxcarbazepine in idiopathic generalized epilepsy. International Journal of Clinical Pharmacology and Therapeutics 50: 300-1, No. 4, Apr 2012 - China 803074255 1 Reactions 28 Jul 2012 No. 1412 0114-9954/10/1412-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Oxcarbazepine
Reactions 1412 - 28 Jul 2012
SOxcarbazepine
Myoclonic seizures in an infant with generalisedtonic-clonic seizures: case report
A 1-year-old female infant developed myoclonic seizuresduring treatment with oxcarbazepine for generalised tonic-clonic seizures (GTCS).
The girl, who had no family history of seizures orepilepsy, had her first GTCS at age 6 months; the seizureslasted for 1–3 minutes at a frequency of 1–3 times a day. CTof the head was normal and an EEG showed no interictalepileptiform activity. She began receiving an oralsuspension of oxcarbazepine [initial dosage not stated]which was titrated up to 22 mg/kg/d. Over the following20 days, she had no further seizures. Then she beganexperiencing clusters of head drops with occasionallybilateral myoclonic movement [duration of treatment toreaction onset not clearly stated]. An EEG revealedgeneralised poly-spike and poly-spike-slow waves.
The girl’s oxcarbazepine was tapered off and thenstopped in 3 days. She began receiving valproate and shehad no further seizures were observed 1 week later. HerEEG gradually normalised over the following 2 months andher subsequent development was age-appropriate.
Author comment: "Although the child was notrechallenged with [oxcarbazepine], it seems likely that herantiepileptic drug regimen did play a role in the myoclonicseizures."Deng S, et al. Myoclonus precipitated by oral suspension of oxcarbazepine inidiopathic generalized epilepsy. International Journal of Clinical Pharmacology andTherapeutics 50: 300-1, No. 4, Apr 2012 - China 803074255
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Reactions 28 Jul 2012 No. 14120114-9954/10/1412-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
