Oxcarbazepine
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Reactions 1242 - 7 Mar 2009 S Oxcarbazepine DRESS syndrome: case report A 13-year-old boy developed DRESS syndrome (drug rash with eosinophilia and systemic symptoms) during treatment with oxcarbazepine for a seizure disorder. After recently starting oxcarbazepine, the boy presented with fever (39.8°C), skin rash and a sore throat [dosage and duration of therapy before reaction not stated]. His BP, pulse and respiratory rates were 138/71mm Hg, 116 beats/min and 22 breaths/min, respectively, and he had an oxygen saturation level of 98%. He had facial swelling, oropharyngeal ulcers and a diffuse confluent morbilliform rash. Clinical examination also revealed diffuse adenopathy and mild right upper quadrant abdominal tenderness. Laboratory testing was notable for a WBC count of 11.5 (8% eosinophils) and an ALT level of 74 IU/L (normal 5–30). Oxcarbazepine was stopped and the boy received IV methylprednisolone and supportive therapies. He then started a 28-day tapered course of oral corticosteroids and was admitted to a paediatric burns unit. He was hospitalised for 7 days and while his symptoms improved on the first day of admission, his rash persisted for several weeks. The results of a skin biopsy were consistent with a hypersensitivity reaction. Subsequently, all antiepileptic drugs were discontinued on the advice of a neurologist. D’Orazio JL. Oxcarbazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS). Clinical Toxicology 46: 1093-1094, No. 10, Dec 2008 - USA 801135853 1 Reactions 7 Mar 2009 No. 1242 0114-9954/10/1242-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
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Transcript of Oxcarbazepine
Reactions 1242 - 7 Mar 2009
SOxcarbazepine
DRESS syndrome: case reportA 13-year-old boy developed DRESS syndrome (drug
rash with eosinophilia and systemic symptoms) duringtreatment with oxcarbazepine for a seizure disorder.
After recently starting oxcarbazepine, the boy presentedwith fever (39.8°C), skin rash and a sore throat [dosage andduration of therapy before reaction not stated]. His BP,pulse and respiratory rates were 138/71mm Hg,116 beats/min and 22 breaths/min, respectively, and hehad an oxygen saturation level of 98%. He had facialswelling, oropharyngeal ulcers and a diffuse confluentmorbilliform rash. Clinical examination also revealeddiffuse adenopathy and mild right upper quadrantabdominal tenderness. Laboratory testing was notable for aWBC count of 11.5 (8% eosinophils) and an ALT level of74 IU/L (normal 5–30).
Oxcarbazepine was stopped and the boy received IVmethylprednisolone and supportive therapies. He thenstarted a 28-day tapered course of oral corticosteroids andwas admitted to a paediatric burns unit. He washospitalised for 7 days and while his symptoms improvedon the first day of admission, his rash persisted for severalweeks. The results of a skin biopsy were consistent with ahypersensitivity reaction. Subsequently, all antiepilepticdrugs were discontinued on the advice of a neurologist.D’Orazio JL. Oxcarbazepine-induced drug reaction with eosinophilia and systemicsymptoms (DRESS). Clinical Toxicology 46: 1093-1094, No. 10, Dec 2008 -USA 801135853
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Reactions 7 Mar 2009 No. 12420114-9954/10/1242-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
