Oxcarbazepine
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Reactions 1197 - 12 Apr 2008 S Oxcarbazepine Haemolytic anaemia in an elderly patient: case report A 75-year-old man developed haemolytic anaemia during treatment with oxcarbazepine for seizure disorders. The man, who was receiving oxcarbazepine [dosage not stated], was hospitalised with a few-day history of lethargy and dark urine discolouration [duration of treatment to reaction onset not stated]. Generalised pallor was evident on examination, and laboratory investigations revealed the following levels and values: WBC count 32/mm 3 , haemoglobin 4.6 g/dL, haematocrit 14%, reticulocyte count 9%, mean corpuscular volume 89fl, mean corpuscular haemoglobin 29 pg/cell, RBC distribution width 25, platelet count 305/mL, lactate dehydrogenase (LDH) 1314 U/L, total bilirubin 3.4 mg/dL and direct bilirubin 0.5 mg/dL. A peripheral blood smear showed polychromasia, microspherocytes and a few nucleated RBCs; 12 RBCs per high power field, haemosiderinuria and moderate bilirubin were revealed by urinalysis. The man received RBC transfusions. Drug-induced haemolytic anaemia was suspected after exclusion of other causes, and oxcarbazepine was stopped. His symptoms improved, his WBC count, haemoglobin level and haematocrit normalised, and reticulocyte count, bilirubin and LDH levels decreased. At 7-month follow-up, he had a haemoglobin level of 11.4 g/dL. Chaudhry MM, et al. Oxcarbazepine-induced hemolytic anemia in a geriatric patient. American Journal of Therapeutics 15: 187-189, No. 2, Mar 2008 - USA 801103660 1 Reactions 12 Apr 2008 No. 1197 0114-9954/10/1197-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Oxcarbazepine
Reactions 1197 - 12 Apr 2008
SOxcarbazepine
Haemolytic anaemia in an elderly patient: casereport
A 75-year-old man developed haemolytic anaemia duringtreatment with oxcarbazepine for seizure disorders.
The man, who was receiving oxcarbazepine [dosage notstated], was hospitalised with a few-day history of lethargy anddark urine discolouration [duration of treatment to reactiononset not stated]. Generalised pallor was evident onexamination, and laboratory investigations revealed thefollowing levels and values: WBC count 32/mm3, haemoglobin4.6 g/dL, haematocrit 14%, reticulocyte count 9%, meancorpuscular volume 89fl, mean corpuscular haemoglobin29 pg/cell, RBC distribution width 25, platelet count 305/mL,lactate dehydrogenase (LDH) 1314 U/L, total bilirubin3.4 mg/dL and direct bilirubin 0.5 mg/dL. A peripheral bloodsmear showed polychromasia, microspherocytes and a fewnucleated RBCs; 12 RBCs per high power field,haemosiderinuria and moderate bilirubin were revealed byurinalysis.
The man received RBC transfusions. Drug-inducedhaemolytic anaemia was suspected after exclusion of othercauses, and oxcarbazepine was stopped. His symptomsimproved, his WBC count, haemoglobin level and haematocritnormalised, and reticulocyte count, bilirubin and LDH levelsdecreased. At 7-month follow-up, he had a haemoglobin levelof 11.4 g/dL.Chaudhry MM, et al. Oxcarbazepine-induced hemolytic anemia in a geriatricpatient. American Journal of Therapeutics 15: 187-189, No. 2, Mar 2008 -USA 801103660
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Reactions 12 Apr 2008 No. 11970114-9954/10/1197-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
