Oxcarbazepine
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Reactions 1283 - 9 Jan 2010 S Oxcarbazepine Exacerbation of seizures in children: 3 case reports Three girls (aged 2–8 years) with partial-onset epilepsy experienced an exacerbation of their seizures after starting oxcarbazepine [dosages and durations of therapy before reaction not stated]. Patient 1 developed staring spells with up-rolling of eyes and eyelid fluttering and became unresponsive after starting oxcarbazepine. She also experienced loss of tone resulting in a fall during some episodes. Generalised spike and wave activity was evident on an ictal EEG. Oxcarbazepine was discontinued and her epilepsy was managed with ethosuximide. After initiation of oxcarbazepine, patient 2 experienced an increase in seizure frequency and developed significant behavioural problems. An interictal EEG showed frequent independent and bilateral centro-temporal spike-wave activity during sleep. Oxcarbazepine was discontinued and she became seizure free under levetiracetam therapy. Patient 3 experienced a marked increase in seizure frequency (increasing to several per day) after starting oxcarbazepine. Generalised spike-wave activity was evident on an ictal EEG. Oxcarbazepine was discontinued and she became seizure free while receiving valproic acid. Harini C, et al. Seizure Exacerbation in Children on Oxcarbazepine. 63rd Annual Meeting of the American Epilepsy Society : abstr. 2.199, 4 Dec 2009. Available from: URL: http://www.aesnet.org [abstract] - USA 803003328 1 Reactions 9 Jan 2010 No. 1283 0114-9954/10/1283-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Oxcarbazepine
Reactions 1283 - 9 Jan 2010
SOxcarbazepine
Exacerbation of seizures in children: 3 casereports
Three girls (aged 2–8 years) with partial-onset epilepsyexperienced an exacerbation of their seizures after startingoxcarbazepine [dosages and durations of therapy beforereaction not stated].
Patient 1 developed staring spells with up-rolling of eyesand eyelid fluttering and became unresponsive afterstarting oxcarbazepine. She also experienced loss of toneresulting in a fall during some episodes. Generalised spikeand wave activity was evident on an ictal EEG.Oxcarbazepine was discontinued and her epilepsy wasmanaged with ethosuximide.
After initiation of oxcarbazepine, patient 2 experiencedan increase in seizure frequency and developed significantbehavioural problems. An interictal EEG showed frequentindependent and bilateral centro-temporal spike-waveactivity during sleep. Oxcarbazepine was discontinued andshe became seizure free under levetiracetam therapy.
Patient 3 experienced a marked increase in seizurefrequency (increasing to several per day) after startingoxcarbazepine. Generalised spike-wave activity wasevident on an ictal EEG. Oxcarbazepine was discontinuedand she became seizure free while receiving valproic acid.Harini C, et al. Seizure Exacerbation in Children on Oxcarbazepine. 63rd AnnualMeeting of the American Epilepsy Society : abstr. 2.199, 4 Dec 2009. Availablefrom: URL: http://www.aesnet.org [abstract] - USA 803003328
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Reactions 9 Jan 2010 No. 12830114-9954/10/1283-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
