Symbole graficzne aparatów, maszyn i urządzeń przemysłu chemicznego
Lorazepam
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Reactions 1219 - 13 Sep 2008 S Lorazepam Respiratory insufficiency in an elderly patient: case report A 70-year-old man developed respiratory insufficiency during treatment with lorazepam. The man, who had a history of Charcot-Marie Tooth disease, coronary artery disease and rectal cancer, presented for central catheter line placement for chemotherapy. He refused to lie flat due to dyspnoea and becoming slightly agitated. He received lorazepam 0.5mg which resulted in acute respiratory insufficiency; this was thought to be caused by lorazepam and diaphragm paralysis [therapeutic indication not clearly stated; time to reaction onset not stated]. The man received supportive treatment and was extubated. He then decompensated and was intubated again due to his inability to support his airways; he was also severely agitated. The second intubation was performed in a sitting position, and dexmedetomidine was given for anxiety. He had a satisfactory outcome, was extubated to bilevel positive airway pressure and was soon weaned to receive oxygen via a nasal cannula [patient outcome not clearly stated]. Shojaee S, et al. Respiratory failure after administration of minimal dose of lorazepam in a patient with Charcot-Marie-Tooth disease. Southern Medical Journal 101: 860, No. 8, Aug 2008 - USA 801123398 1 Reactions 13 Sep 2008 No. 1219 0114-9954/10/1219-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Lorazepam
Reactions 1219 - 13 Sep 2008
SLorazepam
Respiratory insufficiency in an elderly patient: casereport
A 70-year-old man developed respiratory insufficiencyduring treatment with lorazepam.
The man, who had a history of Charcot-Marie Tooth disease,coronary artery disease and rectal cancer, presented for centralcatheter line placement for chemotherapy. He refused to lieflat due to dyspnoea and becoming slightly agitated. Hereceived lorazepam 0.5mg which resulted in acute respiratoryinsufficiency; this was thought to be caused by lorazepam anddiaphragm paralysis [therapeutic indication not clearly stated;time to reaction onset not stated].
The man received supportive treatment and was extubated.He then decompensated and was intubated again due to hisinability to support his airways; he was also severely agitated.The second intubation was performed in a sitting position, anddexmedetomidine was given for anxiety. He had a satisfactoryoutcome, was extubated to bilevel positive airway pressureand was soon weaned to receive oxygen via a nasal cannula[patient outcome not clearly stated].Shojaee S, et al. Respiratory failure after administration of minimal dose oflorazepam in a patient with Charcot-Marie-Tooth disease. Southern MedicalJournal 101: 860, No. 8, Aug 2008 - USA 801123398
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Reactions 13 Sep 2008 No. 12190114-9954/10/1219-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
