Carbazepine/cilostazol
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Reactions 1420 - 22 Sep 2012 S Carbazepine/cilostazol Drug-induced hypersensitivity/DRESS syndrome: case report A 54-year-old man developed drug-induced hypersensitivity (DIHS)/DRESS syndrome while receiving carbamazepine and cilostazol [dosages and routes not stated]. The man had been receiving carbamazepine for 2 weeks for peripheral neuropathy and cilostazol as antiplatelet therapy following a coronary stent placement 3 months earlier. He presented with maculopapular rash on his face, extremities and trunk, and fever. Skin eruptions, myalgia and fever had developed 1 week prior to his admission. Laboratory investigations showed eosinophilia and leucocytosis. Liver function tests suggested cytolytic hepatitis. Histological examination following a skin biopsy showed interface dermatitis with superficial perivascular lymphocytic infiltration. A diagnosis of DIHS/DRESS syndrome was proposed. The man’s medications were discontinued, and he received methylprednisolone. His condition subsequently improved, and methylprednisolone was tapered off. The man subsequently underwent oral challenge testing with carbamazepine and cilostazol. Both drugs induced exfoliative skin rash, eosinophilia and fever. The results of human leukocyte antigen typing were compatible with carbamazepine-induced DIHS/DRESS syndrome. Author comment: "This is the first case report issue to identify cilostazol as a causative agent of DIHS/DRESS syndrome, and to find that cilostazol and [carbamazepine] may act in concert to aggravate DIHS/DRESS syndrome." Kang S-Y, et al. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms syndrome induced by cilostazol and carbamazepine. Journal of Dermatology 39: 723-724, No. 8, Aug 2012. Available from: URL: http://dx.doi.org/10.1111/j.1346-8138.2011.01500.x - South Korea 803077425 1 Reactions 22 Sep 2012 No. 1420 0114-9954/10/1420-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Carbazepine/cilostazol
Reactions 1420 - 22 Sep 2012
SCarbazepine/cilostazol
Drug-induced hypersensitivity/DRESS syndrome:case report
A 54-year-old man developed drug-inducedhypersensitivity (DIHS)/DRESS syndrome while receivingcarbamazepine and cilostazol [dosages and routes notstated].
The man had been receiving carbamazepine for 2 weeksfor peripheral neuropathy and cilostazol as antiplatelettherapy following a coronary stent placement 3 monthsearlier. He presented with maculopapular rash on his face,extremities and trunk, and fever. Skin eruptions, myalgiaand fever had developed 1 week prior to his admission.Laboratory investigations showed eosinophilia andleucocytosis. Liver function tests suggested cytolytichepatitis. Histological examination following a skin biopsyshowed interface dermatitis with superficial perivascularlymphocytic infiltration. A diagnosis of DIHS/DRESSsyndrome was proposed.
The man’s medications were discontinued, and hereceived methylprednisolone. His condition subsequentlyimproved, and methylprednisolone was tapered off.
The man subsequently underwent oral challenge testingwith carbamazepine and cilostazol. Both drugs inducedexfoliative skin rash, eosinophilia and fever. The results ofhuman leukocyte antigen typing were compatible withcarbamazepine-induced DIHS/DRESS syndrome.
Author comment: "This is the first case report issue toidentify cilostazol as a causative agent of DIHS/DRESSsyndrome, and to find that cilostazol and [carbamazepine]may act in concert to aggravate DIHS/DRESS syndrome."Kang S-Y, et al. Drug-induced hypersensitivity syndrome/drug reaction witheosinophilia and systemic symptoms syndrome induced by cilostazol andcarbamazepine. Journal of Dermatology 39: 723-724, No. 8, Aug 2012. Availablefrom: URL: http://dx.doi.org/10.1111/j.1346-8138.2011.01500.x - SouthKorea 803077425
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Reactions 22 Sep 2012 No. 14200114-9954/10/1420-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
