Carbamazepine/chlorpromazine/risperidone
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Reactions 1342 - 12 Mar 2011 Carbamazepine/chlorpromazine/ risperidone Dystonia, hepatitis, difficulty swallowing and glossitis: case report A 52-year-old woman who was admitted with a severe manic episode developed dystonia during treatment with risperidone, mild glossitis with difficulty swallowing under carbamazepine, and hepatitis attributed to chlorpromazine [routes and durations of treatments to reaction onsets not stated]. During her admission the woman, who had a history of mood stabiliser discontinuations due to side effects, began receiving risperidone 8 mg/day in divided doses, carbamazepine 600mg twice daily, and clonazepam 2-3 mg/day. Chlorpromazine up to 500 mg/day was later added. After about 2 weeks, she developed dystonia. Risperidone was discontinued and she recovered. After a short time she also developed trouble swallowing and mild glossitis; chlorpromazine was switched to perphenazine [outcome not stated]. After a symptomatic worsening, her perphenazine dosage was increased; two weeks later she developed elevated liver transaminases, fever and transient hypotension. Carbamazepine was withdrawn and she received fluids, and improved. Investigations revealed no source for her fever. Her hepatitis was suspected to be carbamazepine-induced, and she recovered. Robinson LA, et al. Electroconvulsive therapy for the treatment of refractory mania. Journal of Psychiatric Practice 17: 61-66, No. 1, Jan 2011. Available from: URL: http://dx.doi.org/10.1097/01.pra.0000393847.58003.8f - USA 803050917 1 Reactions 12 Mar 2011 No. 1342 0114-9954/10/1342-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine/chlorpromazine/risperidone
Reactions 1342 - 12 Mar 2011
Carbamazepine/chlorpromazine/risperidone
Dystonia, hepatitis, difficulty swallowing andglossitis: case report
A 52-year-old woman who was admitted with a severemanic episode developed dystonia during treatment withrisperidone, mild glossitis with difficulty swallowing undercarbamazepine, and hepatitis attributed to chlorpromazine[routes and durations of treatments to reaction onsets notstated].
During her admission the woman, who had a history ofmood stabiliser discontinuations due to side effects, beganreceiving risperidone 8 mg/day in divided doses,carbamazepine 600mg twice daily, and clonazepam2-3 mg/day. Chlorpromazine up to 500 mg/day was lateradded.
After about 2 weeks, she developed dystonia.Risperidone was discontinued and she recovered.
After a short time she also developed trouble swallowingand mild glossitis; chlorpromazine was switched toperphenazine [outcome not stated].
After a symptomatic worsening, her perphenazinedosage was increased; two weeks later she developedelevated liver transaminases, fever and transienthypotension. Carbamazepine was withdrawn and shereceived fluids, and improved. Investigations revealed nosource for her fever. Her hepatitis was suspected to becarbamazepine-induced, and she recovered.Robinson LA, et al. Electroconvulsive therapy for the treatment of refractorymania. Journal of Psychiatric Practice 17: 61-66, No. 1, Jan 2011. Available from:URL: http://dx.doi.org/10.1097/01.pra.0000393847.58003.8f - USA 803050917
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Reactions 12 Mar 2011 No. 13420114-9954/10/1342-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
