Carbamazepine overdose
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Reactions 442 - 13 Mar 1993 S Carbamazepine overdose Acute pancreatitis in a child: case report The morning after accidental ingestion of carbamazepine (amount taken not known), a 5-year-old boy became lethargic and began vomiting. The boy had received carbamazepine in the past for epilepsy, but had not been taking the agent for 5 months. On admission, his serum carbamazepine concentration was 21 mg/ml. His serum amylase level was 291 U/L (normal 0-110 U/L) and serum lipase was 1379 U/L (normal 25-110 U/L). IV fluids and electrolytes, dietary modification, oral pancrelipase and ranitidine resulted in a rapid improvement in the boy’s condition. By day 3, his serum carbamazepine concentration had decreased to 4.4 mg/ml. However, serum amylase and lipase levels remained elevated during hospitalisation He was discharged after 1 week and follow-up several weeks later showed normal serum amylase and lipase levels. Author comment: Possible cases of carbamazepine-induced pancreatitis have occurred previously. Although rechallenge with carbamazepine was not performed in the above patient, the occurrence of acute chemical pancreatitis was ‘most likely’ associated with carbamazepine intoxication Tsao CY, et al. Acute chemical pancreatitis associated with carbamazepine intoxication. Epilepsia 34: 174-176, Jan-Feb 1993 - USA 800183470 1 Reactions 13 Mar 1993 No. 442 0114-9954/10/0442-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Carbamazepine overdose
Reactions 442 - 13 Mar 1993
SCarbamazepine overdose
Acute pancreatitis in a child: case reportThe morning after accidental ingestion of carbamazepine
(amount taken not known), a 5-year-old boy became lethargicand began vomiting. The boy had received carbamazepine inthe past for epilepsy, but had not been taking the agent for 5months. On admission, his serum carbamazepineconcentration was 21 mg/ml. His serum amylase level was 291U/L (normal 0-110 U/L) and serum lipase was 1379 U/L(normal 25-110 U/L). IV fluids and electrolytes, dietarymodification, oral pancrelipase and ranitidine resulted in arapid improvement in the boy’s condition. By day 3, his serumcarbamazepine concentration had decreased to 4.4 mg/ml.However, serum amylase and lipase levels remained elevatedduring hospitalisation He was discharged after 1 week andfollow-up several weeks later showed normal serum amylaseand lipase levels.
Author comment: Possible cases of carbamazepine-inducedpancreatitis have occurred previously. Although rechallengewith carbamazepine was not performed in the above patient,the occurrence of acute chemical pancreatitis was ‘most likely’associated with carbamazepine intoxicationTsao CY, et al. Acute chemical pancreatitis associated with carbamazepineintoxication. Epilepsia 34: 174-176, Jan-Feb 1993 - USA 800183470
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Reactions 13 Mar 1993 No. 4420114-9954/10/0442-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
