Carbamazepine overdose
1
Reactions 1414 - 11 Aug 2012 O S Carbamazepine overdose Central nervous system depression: case report A 19-year-old woman experienced CNS depression after taking an excessive dose of carbamazepine in a suicide attempt. The woman was admitted to an emergency department (ED) after taking carbamazepine 8000mg (186 mg/kg) [route not stated]; it was her third suicide attempt. Her pupils were isocoric and mydriatic and Glasgow Coma Scale was 7 [time to reaction onset not stated]. Her blood pressure was 70/40mm Hg and her body temperature was 36.1°C. The woman received isotonic fluid therapy and charcoal in the ED, and this was repeated following her admission to an ICU. She also received haemodialysis. Her serum levels of carbamazepine decreased from 57.7 µg/mL before haemodialysis to 28.9 µg/mL. On the third day, she was conscious with a GCS of 15. On the fifth day, she was transferred to a psychiatric clinic as she was having persistent suicidal thoughts. Author comment: "[W]e report a 19-year-old woman with fatal-dose carbamazepine intoxication who was treated successfully with multiple-dose activated charcoal and haemodialysis." Yaylaci S, et al. Successful treatment of excessive dose of carbamazepine. Indian Journal of Pharmacology 44: 417-418, No. 3, Jun 2012. Available from: URL: http://dx.doi.org/10.4103/0253-7613.96353 - Turkey 803075358 1 Reactions 11 Aug 2012 No. 1414 0114-9954/10/1414-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine overdose
Reactions 1414 - 11 Aug 2012
O SCarbamazepine overdose
Central nervous system depression: case reportA 19-year-old woman experienced CNS depression after
taking an excessive dose of carbamazepine in a suicideattempt.
The woman was admitted to an emergency department(ED) after taking carbamazepine 8000mg (186 mg/kg)[route not stated]; it was her third suicide attempt. Herpupils were isocoric and mydriatic and Glasgow ComaScale was 7 [time to reaction onset not stated]. Her bloodpressure was 70/40mm Hg and her body temperature was36.1°C. The woman received isotonic fluid therapy andcharcoal in the ED, and this was repeated following heradmission to an ICU. She also received haemodialysis. Herserum levels of carbamazepine decreased from 57.7 µg/mLbefore haemodialysis to 28.9 µg/mL. On the third day, shewas conscious with a GCS of 15. On the fifth day, she wastransferred to a psychiatric clinic as she was havingpersistent suicidal thoughts.
Author comment: "[W]e report a 19-year-old woman withfatal-dose carbamazepine intoxication who was treatedsuccessfully with multiple-dose activated charcoal andhaemodialysis."Yaylaci S, et al. Successful treatment of excessive dose of carbamazepine. IndianJournal of Pharmacology 44: 417-418, No. 3, Jun 2012. Available from: URL:http://dx.doi.org/10.4103/0253-7613.96353 - Turkey 803075358
1
Reactions 11 Aug 2012 No. 14140114-9954/10/1414-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
