Carbamazepine overdose
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Reactions 1330 - 4 Dec 2010 O S Carbamazepine overdose Unconsciousness and seizures in a child: case report A 7-year-old boy lost consciousness and developed seizures following ingestion of a carbamazepine overdose. The boy had been prescribed carbamazepine tablets 200mg twice daily for epilepsy, diagnosed 2 years earlier. However, 6 hours before presentation, he had taken 10 tablets, equal to 100 mg/kg and had become unconscious 1 hour later. He vomited three times at home. On presentation, he appeared ill, with decreased consciousness (Glasgow Coma Scale score 6) and stupor. He was hospitalised with a diagnosis of acute carbamazepine intoxication. The boy underwent gastric lavage and was administered activated charcoal. He developed seizures 12 hours after hospitalisation and was treated with diazepam. His serum carbamazepine concentration was 25 µg/mL on hospital day 3. The next day, his brain MRI was normal and he was discharged. He started phenytoin therapy. Two months later, he had normal neurological function and there had been no recurrence of seizures. Dogan M, et al. A case of carbamazepine intoxication in a young boy. Journal of Emergency Medicine 39: 655-656, No. 5, Nov 2010. Available from: URL: http:// dx.doi.org/10.1016/j.jemermed.2008.10.007 - Turkey 803044765 1 Reactions 4 Dec 2010 No. 1330 0114-9954/10/1330-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
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Transcript of Carbamazepine overdose
Reactions 1330 - 4 Dec 2010
O SCarbamazepine overdose
Unconsciousness and seizures in a child: casereport
A 7-year-old boy lost consciousness and developedseizures following ingestion of a carbamazepine overdose.
The boy had been prescribed carbamazepine tablets200mg twice daily for epilepsy, diagnosed 2 years earlier.However, 6 hours before presentation, he had taken10 tablets, equal to 100 mg/kg and had becomeunconscious 1 hour later. He vomited three times at home.On presentation, he appeared ill, with decreasedconsciousness (Glasgow Coma Scale score 6) and stupor.He was hospitalised with a diagnosis of acutecarbamazepine intoxication.
The boy underwent gastric lavage and was administeredactivated charcoal. He developed seizures 12 hours afterhospitalisation and was treated with diazepam. His serumcarbamazepine concentration was 25 µg/mL on hospitalday 3. The next day, his brain MRI was normal and he wasdischarged. He started phenytoin therapy. Two monthslater, he had normal neurological function and there hadbeen no recurrence of seizures.Dogan M, et al. A case of carbamazepine intoxication in a young boy. Journal ofEmergency Medicine 39: 655-656, No. 5, Nov 2010. Available from: URL: http://dx.doi.org/10.1016/j.jemermed.2008.10.007 - Turkey 803044765
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Reactions 4 Dec 2010 No. 13300114-9954/10/1330-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
