Carbamazepine overdose
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Reactions 677 - 15 Nov 1997 ★ S Carbamazepine overdose First report of neuromuscular transmission defect: 2 case reports Two boys, aged 13 and 14 years, were both hospitalised in a coma, with diffuse hypotonia, areflexia, absent oculocephalic reflex and unreactive pupils after they ingested carbamazepine [dose not stated], possibly as a suicide attempt. Electromyographs showed a 60% decrement was evident with 50Hz stimulation of the extensor brevis. The patients’ serum carbamazepine concentrations were 46.8 and 28.6 mg/ dl. The boys recovered uneventfully after supportive care and their follow-up electromyographs were normal. Author comment: ‘This is the first clinical report of a neuromuscular transmission defect produced by carbamazepine. We postulate carbamazepine’s known effect on decreasing sodium channel depolarization produced a presynaptic defect in neuromuscular transmission.’ Zaidat O, et al. Neuromuscular transmission defect caused by carbamazepine. Annals of Neurology 42: 453, Sep 1997 [abstract] - USA 800623207 1 Reactions 15 Nov 1997 No. 677 0114-9954/10/0677-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine overdose
Reactions 677 - 15 Nov 1997
★ SCarbamazepine overdose
First report of neuromuscular transmission defect:2 case reports
Two boys, aged 13 and 14 years, were both hospitalised in acoma, with diffuse hypotonia, areflexia, absent oculocephalicreflex and unreactive pupils after they ingested carbamazepine[dose not stated], possibly as a suicide attempt.
Electromyographs showed a 60% decrement was evidentwith 50Hz stimulation of the extensor brevis. The patients’serum carbamazepine concentrations were 46.8 and 28.6 mg/dl.
The boys recovered uneventfully after supportive care andtheir follow-up electromyographs were normal.
Author comment: ‘This is the first clinical report of aneuromuscular transmission defect produced bycarbamazepine. We postulate carbamazepine’s known effecton decreasing sodium channel depolarization produced apresynaptic defect in neuromuscular transmission.’Zaidat O, et al. Neuromuscular transmission defect caused by carbamazepine.Annals of Neurology 42: 453, Sep 1997 [abstract] - USA 800623207
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Reactions 15 Nov 1997 No. 6770114-9954/10/0677-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
