Carbamazepine
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Reactions 978 - 22 Nov 2003 S Carbamazepine Transient brain lesion: case report A 24-year-old woman developed a transient brain lesion, in the splenium of the corpus callosum (SCC), while receiving carbamazepine for epilepsy. The woman, who had been admitted to hospital with complaints of compulsion and headache, started receiving carbamazepine 400 mg/day for suspected epilepsy 12 days after admission. Carbamazepine was withdrawn on day 33 due to leucocytopenia (WBC count 2400/µL) and she started treatment with levomepromazine and chlorpromazine. On day 44, brain MRI showed a clear, well-defined lesion in her SCC with reduced T1 and increased T2 signal intensities, but she had no abnormal neurological findings or interhemispheric symptoms. Cerebrospinal fluid analysis was unremarkable. On day 51, MRI showed a decrease in lesion size and by day 68 it had virtually disappeared. An EEG showed no epileptic discharges on day 90. Her headaches and compulsion resolved and she was discharged on day 118. Six months later her lesion had completely disappeared. Author comment: "The present case demonstrated a transient lesion in the SCC on brain MRI, similar to that of AED [antiepileptic drugs], during administration or soon after withdrawal of carbamazepine." Narita H, et al. Transient lesion in the splenium of the corpus callosum, possibly due to carbamazepine. Psychiatry and Clinical Neurosciences 57: 550-551, No. 5, Oct 2003 - Japan 800960616 1 Reactions 22 Nov 2003 No. 978 0114-9954/10/0978-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 978 - 22 Nov 2003
SCarbamazepine
Transient brain lesion: case reportA 24-year-old woman developed a transient brain lesion, in
the splenium of the corpus callosum (SCC), while receivingcarbamazepine for epilepsy.
The woman, who had been admitted to hospital withcomplaints of compulsion and headache, started receivingcarbamazepine 400 mg/day for suspected epilepsy 12 daysafter admission. Carbamazepine was withdrawn on day 33 dueto leucocytopenia (WBC count 2400/µL) and she startedtreatment with levomepromazine and chlorpromazine. Onday 44, brain MRI showed a clear, well-defined lesion in herSCC with reduced T1 and increased T2 signal intensities, butshe had no abnormal neurological findings orinterhemispheric symptoms. Cerebrospinal fluid analysis wasunremarkable. On day 51, MRI showed a decrease in lesionsize and by day 68 it had virtually disappeared. An EEG showedno epileptic discharges on day 90. Her headaches andcompulsion resolved and she was discharged on day 118. Sixmonths later her lesion had completely disappeared.
Author comment: "The present case demonstrated atransient lesion in the SCC on brain MRI, similar to that ofAED [antiepileptic drugs], during administration or soon afterwithdrawal of carbamazepine."Narita H, et al. Transient lesion in the splenium of the corpus callosum, possiblydue to carbamazepine. Psychiatry and Clinical Neurosciences 57: 550-551, No. 5,Oct 2003 - Japan 800960616
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Reactions 22 Nov 2003 No. 9780114-9954/10/0978-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
