Carbamazepine
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Reactions 599 - 4 May 1996 S Carbamazepine Aseptic meningitis: case report Carbamazepine was the most likely cause of aseptic meningitis in a 41-year-old woman who had taken the agent for trigeminal neuralgia. The woman had been prescribed carbamazepine 600 mg/day 6 months prior to hospitalisation. After approximately 1 month of treatment, she stopped taking the agent. About 5 months later, she restarted carbamazepine at a dosage of 300 mg/day because of right-sided facial pain. Ten days later, she was hospitalised with a 3-day history of a fever, chills, a stiff neck, photophobia, myalgia, and a diffuse maculopapular rash. An examination on admission revealed meningismus, and the woman was initially treated with IV ceftriaxone. On hospital day 3, she experienced worsening right-sided facial pain and the dosage of carbamazepine was increased to 600 mg/day. She continued to experience headaches and fever, and was treated with further antibacterials. However, the maculopapular rash persisted, and on hospital day 7 carbamazepine was stopped. On day 8 she continued to experience meningeal signs and fever. An examination following transferral to another hospital showed nuchal rigidity, her peripheral WBC count was 8200/mm 3 with 83% neutrophils, and her liver enzyme levels were elevated. Antibacterial therapy was stopped, and within 24 hours the woman’s fever resolved. The maculopapular rash and nuchal rigidity also resolved, and she was discharged 48 hours later. Her meningeal symptoms did not recur over a 1-year follow-up period. Author comment: ‘To date, only three [previous] cases of aseptic meningitis associated with the administration of carbamazepine have been reported in the United States.’ Dang CT, et al. Aseptic meningitis secondary to carbamazepine therapy. Clinical Infectious Diseases 22: 729-730, Apr 1996 - USA 800435056 1 Reactions 4 May 1996 No. 599 0114-9954/10/0599-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 599 - 4 May 1996
SCarbamazepine
Aseptic meningitis: case reportCarbamazepine was the most likely cause of aseptic
meningitis in a 41-year-old woman who had taken the agentfor trigeminal neuralgia.
The woman had been prescribed carbamazepine 600mg/day 6 months prior to hospitalisation. After approximately1 month of treatment, she stopped taking the agent. About 5months later, she restarted carbamazepine at a dosage of 300mg/day because of right-sided facial pain. Ten days later, shewas hospitalised with a 3-day history of a fever, chills, a stiffneck, photophobia, myalgia, and a diffuse maculopapular rash.
An examination on admission revealed meningismus, andthe woman was initially treated with IV ceftriaxone. Onhospital day 3, she experienced worsening right-sided facialpain and the dosage of carbamazepine was increased to 600mg/day. She continued to experience headaches and fever,and was treated with further antibacterials. However, themaculopapular rash persisted, and on hospital day 7carbamazepine was stopped. On day 8 she continued toexperience meningeal signs and fever.
An examination following transferral to another hospitalshowed nuchal rigidity, her peripheral WBC count was8200/mm3 with 83% neutrophils, and her liver enzyme levelswere elevated. Antibacterial therapy was stopped, and within24 hours the woman’s fever resolved. The maculopapular rashand nuchal rigidity also resolved, and she was discharged 48hours later. Her meningeal symptoms did not recur over a1-year follow-up period.
Author comment: ‘To date, only three [previous] cases ofaseptic meningitis associated with the administration ofcarbamazepine have been reported in the United States.’Dang CT, et al. Aseptic meningitis secondary to carbamazepine therapy. ClinicalInfectious Diseases 22: 729-730, Apr 1996 - USA 800435056
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Reactions 4 May 1996 No. 5990114-9954/10/0599-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
