Carbamazepine
1
Reactions 430 - 5 Dec 1992 Carbamazepine Cutaneous lymphoproliferative disorder: case report A nodular cutaneous lymphoproliferative disorder developed in a 63-year-old diabetic man who received 8 months of carbamazepine 400 mg/day for painful neuropathy of the legs. On admission he had a 4 month history of skin lesions and examination revealed numerous nonscaling nodules on his scalp, face and the upper part of his trunk. Skin biopsy of a scalp nodule revealed a diffuse, dense dermal infiltrate which extended into the epidermis. Six days after admission carbamazepine was discontinued and all the nodules resolved within 3 weeks. Author comment: The clinical, histological and immunohistochemical findings suggested the lesions were benign. Although the patient was not rechallenged with the drug, it appears likely that carbamazepine was responsible for provocation of these lesions. However, coincidental occurrence of a true malignant lymphoma cannot be entirely excluded, as both T- and B-cell lymphomas may show spontaneous regression. In the present case, no B-lymphoid- cell monoclonality was demonstrated, but gene rearrangement to establish a T-cell lymphoid monoclonality was not performed Sigal-Nahum M, et al. A nodular cutaneous lymphoproliferative disorder during carbamazepine administration. British Journal of Pharmacology 127: 545-547, Nov 1992 - France 800167596 1 Reactions 5 Dec 1992 No. 430 0114-9954/10/0430-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 430 - 5 Dec 1992
Carbamazepine
Cutaneous lymphoproliferative disorder: casereport
A nodular cutaneous lymphoproliferative disorderdeveloped in a 63-year-old diabetic man who received 8months of carbamazepine 400 mg/day for painful neuropathyof the legs. On admission he had a 4 month history of skinlesions and examination revealed numerous nonscalingnodules on his scalp, face and the upper part of his trunk. Skinbiopsy of a scalp nodule revealed a diffuse, dense dermalinfiltrate which extended into the epidermis. Six days afteradmission carbamazepine was discontinued and all thenodules resolved within 3 weeks.
Author comment: The clinical, histological andimmunohistochemical findings suggested the lesions werebenign. Although the patient was not rechallenged with thedrug, it appears likely that carbamazepine was responsible forprovocation of these lesions. However, coincidentaloccurrence of a true malignant lymphoma cannot be entirelyexcluded, as both T- and B-cell lymphomas may showspontaneous regression. In the present case, no B-lymphoid-cell monoclonality was demonstrated, but gene rearrangementto establish a T-cell lymphoid monoclonality was notperformedSigal-Nahum M, et al. A nodular cutaneous lymphoproliferative disorder duringcarbamazepine administration. British Journal of Pharmacology 127: 545-547, Nov1992 - France 800167596
1
Reactions 5 Dec 1992 No. 4300114-9954/10/0430-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
