Carbamazepine
1
Reactions 442 - 13 Mar 1993 Carbamazepine Renal failure: case report Acute renal failure developed in a 38-year-old man who had been treated for 4 years with carbamazepine 400mg tid for epilepsy and oxazepam for anxiety. The patient was admitted after a period of unconsciousness His serum creatinine, potassium, sodium, AST, ALT, lactic dehydrogenase and creatine kinase levels were raised. The man’s acidosis was treated with sodium bicarbonate and his hyperkalaemia with sodium polystyrene sulfonate. Carbamazepine was discontinued and replaced with phenytoin The patient’s serum creatinine levels, which reached a maximum of 1017 micromol/L, normalised to 91 micromol/L over 3 weeks, at which time the patient was discharged Hegbrant J, et al. Carbamazepine-related acute renal failure. Neurology 43: 446-447, Feb 1993 - Sweden 800181216 1 Reactions 13 Mar 1993 No. 442 0114-9954/10/0442-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Carbamazepine
Reactions 442 - 13 Mar 1993
Carbamazepine
Renal failure: case reportAcute renal failure developed in a 38-year-old man who had
been treated for 4 years with carbamazepine 400mg tid forepilepsy and oxazepam for anxiety. The patient was admittedafter a period of unconsciousness His serum creatinine,potassium, sodium, AST, ALT, lactic dehydrogenase andcreatine kinase levels were raised. The man’s acidosis wastreated with sodium bicarbonate and his hyperkalaemia withsodium polystyrene sulfonate. Carbamazepine wasdiscontinued and replaced with phenytoin The patient’s serumcreatinine levels, which reached a maximum of 1017micromol/L, normalised to 91 micromol/L over 3 weeks, atwhich time the patient was dischargedHegbrant J, et al. Carbamazepine-related acute renal failure. Neurology 43:446-447, Feb 1993 - Sweden 800181216
1
Reactions 13 Mar 1993 No. 4420114-9954/10/0442-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
