Carbamazepine
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Reactions 438 - 13 Feb 1993 Carbamazepine Liver disorders in a neonate following administration: case report Transient hepatic dysfunction occurred in a full-term neonate with ABO haemolytic disease during her first day of life. Her 23-year-old mother had been receiving carbamazepine 400 mg/day during the pregnancy and postpartum for epilepsy. Hepatic dysfunction in the neonate was characterised by direct hyperbilirubinaemia and high levels of gamma glutamyltransferase (GGT); other hepatic enzyme levels were normal. The frequency of breastfeeding was reduced 9 days after the neonate was delivered and her hepatic dysfunction resolved, despite the mother continuing to receive the same dose of carbamazepine Hyperbilirubinaemia resolved within 2 weeks, whereas elevated GGT levels (377 U/L on day 5) slowly decreased to 81 U/L by day 63. Author comment: ‘The hepatic dysfunction in this infant was very different from that of the only previously described case of cholestatic hepatitis’ in a neonate associated with maternal carbamazepine therapy (see European Journal of Pediatrics 150: 136-138, 1990) Merlob P, et al. Transient hepatic dysfunction in an infant of an epileptic mother treated with carbamazepine during pregnancy and breastfeeding. Annals of Pharmacotherapy 26: 1563-1565, Dec 1992 - Israel 800177886 1 Reactions 13 Feb 1993 No. 438 0114-9954/10/0438-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 438 - 13 Feb 1993
Carbamazepine
Liver disorders in a neonate followingadministration: case report
Transient hepatic dysfunction occurred in a full-termneonate with ABO haemolytic disease during her first day oflife. Her 23-year-old mother had been receivingcarbamazepine 400 mg/day during the pregnancy andpostpartum for epilepsy. Hepatic dysfunction in the neonatewas characterised by direct hyperbilirubinaemia and highlevels of gamma glutamyltransferase (GGT); other hepaticenzyme levels were normal. The frequency of breastfeedingwas reduced 9 days after the neonate was delivered and herhepatic dysfunction resolved, despite the mother continuing toreceive the same dose of carbamazepine Hyperbilirubinaemiaresolved within 2 weeks, whereas elevated GGT levels (377U/L on day 5) slowly decreased to 81 U/L by day 63.
Author comment: ‘The hepatic dysfunction in this infant wasvery different from that of the only previously described caseof cholestatic hepatitis’ in a neonate associated with maternalcarbamazepine therapy (see European Journal of Pediatrics150: 136-138, 1990)Merlob P, et al. Transient hepatic dysfunction in an infant of an epileptic mothertreated with carbamazepine during pregnancy and breastfeeding. Annals ofPharmacotherapy 26: 1563-1565, Dec 1992 - Israel 800177886
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Reactions 13 Feb 1993 No. 4380114-9954/10/0438-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
