Carbamazepine
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Reactions 1411 - 21 Jul 2012 S Carbamazepine Lichen planus in an elderly patient: case report A 71-year-old woman developed lichen planus following long-term therapy with carbamazepine for temporal lobe epilepsy. The woman had received carbamazepine monotherapy since 1984 after unsuccessfully trialling various antiepileptic drugs. She had received a maintenance regimen of carbamazepine 400mg twice daily [route not stated] for approximately 5 years prior to presentation. In November 2009, she noticed non-itching erythematous papulosquamous papules on her trunk, legs and under her breasts [time to reaction onset not stated]. Upon hospitalisation the predominant symptom had evolved to itching of the feet. On clinical examination, erythematosquamous papules were evident on her abdomen and scapular region alongside desquamation and yellowish-erythematous discolouration of the skin on the palms of her hands and the soles of her feet. Skin biopsy confirmed lichen planus in exanthematous form. Carbamazepine was implicated followed a positive in vitro lymphocyte transformation test. Carbamazepine was discontinued and replaced with oxcarbazepine. The woman was treated with corticosteroids and neutral preparations under occlusion. Her skin changes regressed with her skin pigmentation becoming brown. Topical therapy with betamethasone in a neutral base was continued following discharge. Author comment: "We report a case of a patient with a history of complex partial seizures with secondary generalization, who developed Lichen planus as side effect of long-term carbamazepine therapy." Hajnsek S, et al. Lichen planus induced by carbamazepine: A case report. Epilepsy and Behavior 24: 269-271, No. 2, Jun 2012. Available from: URL: http:// dx.doi.org/10.1016/j.yebeh.2012.03.037 - Croatia 803073871 1 Reactions 21 Jul 2012 No. 1411 0114-9954/10/1411-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 1411 - 21 Jul 2012
SCarbamazepine
Lichen planus in an elderly patient: case reportA 71-year-old woman developed lichen planus following
long-term therapy with carbamazepine for temporal lobeepilepsy.
The woman had received carbamazepine monotherapysince 1984 after unsuccessfully trialling variousantiepileptic drugs. She had received a maintenanceregimen of carbamazepine 400mg twice daily [route notstated] for approximately 5 years prior to presentation. InNovember 2009, she noticed non-itching erythematouspapulosquamous papules on her trunk, legs and under herbreasts [time to reaction onset not stated]. Uponhospitalisation the predominant symptom had evolved toitching of the feet. On clinical examination,erythematosquamous papules were evident on herabdomen and scapular region alongside desquamation andyellowish-erythematous discolouration of the skin on thepalms of her hands and the soles of her feet. Skin biopsyconfirmed lichen planus in exanthematous form.Carbamazepine was implicated followed a positive in vitrolymphocyte transformation test.
Carbamazepine was discontinued and replaced withoxcarbazepine. The woman was treated withcorticosteroids and neutral preparations under occlusion.Her skin changes regressed with her skin pigmentationbecoming brown. Topical therapy with betamethasone in aneutral base was continued following discharge.
Author comment: "We report a case of a patient with ahistory of complex partial seizures with secondarygeneralization, who developed Lichen planus as side effect oflong-term carbamazepine therapy."Hajnsek S, et al. Lichen planus induced by carbamazepine: A case report. Epilepsyand Behavior 24: 269-271, No. 2, Jun 2012. Available from: URL: http://dx.doi.org/10.1016/j.yebeh.2012.03.037 - Croatia 803073871
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Reactions 21 Jul 2012 No. 14110114-9954/10/1411-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
