Carbamazepine
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Reactions 1384 - 14 Jan 2012 S Carbamazepine DRESS syndrome/drug-induced hypersensitivity syndrome: case report A 15-year-old boy developed DRESS syndrome/drug- induced hypersensitivity syndrome following treatment with carbamazepine for epilepsy. The boy was hospitalised with pyrexia and a generalised itchy rash after receiving carbamazepine over 5 weeks [route, dosage and duration of treatment to reaction onset not stated]. Small follicular pustules located to the extremities and trunk in addition to facial oedema were observed with cervical lymphadenopathy. The results of a skin biopsy showed a spongiotic pustule in the follicular infundibulum associated with dermal perivascular lymphocytic, neutrophilic and eosinophilic infiltrations. Tests revealed the following values: WBC count 12 000/mL with up to 5% atypical lymphocytes, AST 367 IU/L and ALT 1637 IU/L; eosinophilia and a positive result for human herpes virus were also noted. Prednisone was initiated, and the boy’s condition regressed. Author comment: "This case fulfils the criteria for both DIHS [drug-induced hypersensitivity syndrome] (7/7 of the Japanese consensus group criteria) and DRESS (8/9 of the Kardaun et al. criteria). The mechanism of DIHS/DRESS has not been fully elucidated." Ueharaguchi Y, et al. Multiple follicular pustules as an atypical cutaneous manifestation of drug-induced hypersensitivity syndrome. Acta Dermato- Venereologica 91: 728-729, No. 6, Oct 2011. Available from: URL: http:// dx.doi.org/10.2340/00015555-1152 - Japan 803065259 1 Reactions 14 Jan 2012 No. 1384 0114-9954/10/1384-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine
Reactions 1384 - 14 Jan 2012
SCarbamazepine
DRESS syndrome/drug-induced hypersensitivitysyndrome: case report
A 15-year-old boy developed DRESS syndrome/drug-induced hypersensitivity syndrome following treatmentwith carbamazepine for epilepsy.
The boy was hospitalised with pyrexia and a generaliseditchy rash after receiving carbamazepine over 5 weeks[route, dosage and duration of treatment to reaction onsetnot stated]. Small follicular pustules located to theextremities and trunk in addition to facial oedema wereobserved with cervical lymphadenopathy. The results of askin biopsy showed a spongiotic pustule in the follicularinfundibulum associated with dermal perivascularlymphocytic, neutrophilic and eosinophilic infiltrations.Tests revealed the following values: WBC count 12 000/mLwith up to 5% atypical lymphocytes, AST 367 IU/L and ALT1637 IU/L; eosinophilia and a positive result for humanherpes virus were also noted.
Prednisone was initiated, and the boy’s conditionregressed.
Author comment: "This case fulfils the criteria for bothDIHS [drug-induced hypersensitivity syndrome] (7/7 of theJapanese consensus group criteria) and DRESS (8/9 of theKardaun et al. criteria). The mechanism of DIHS/DRESS hasnot been fully elucidated."Ueharaguchi Y, et al. Multiple follicular pustules as an atypical cutaneousmanifestation of drug-induced hypersensitivity syndrome. Acta Dermato-Venereologica 91: 728-729, No. 6, Oct 2011. Available from: URL: http://dx.doi.org/10.2340/00015555-1152 - Japan 803065259
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Reactions 14 Jan 2012 No. 13840114-9954/10/1384-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
