Carbamazepine
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Reactions 1447 - 13 Apr 2013 S Carbamazepine Neutrophilic eccrine hidradenitis: case report A 40-year-old woman developed neutrophilic eccrine hidradenitis while receiving carbamazepine for epilepsy. The woman was admitted to hospital with fever, puffiness of face, vomiting and skin rash for 5 days. She had been receiving carbamazepine for 1 month [route and dosage not stated] to treat epilepsy. A dermatological examination revealed multiple nonscaly, dry, round-to-oval, discretely arranged bilaterally near symmetrical nodules, pustules, vesicles and papules on her hands and forearms. There was mild skin peeling observed over her abdomen and proximal areas of her upper and lower limbs. Histological analysis of a skin biopsy from her right forearm showed a neutrophilic infiltrate surrounding the eccrine glands and sparing the duct. A focal interface vacuolar dermatitis was evident. Some histiocytes and scattered lymphocytes were seen within the dermis. The woman was started on oral corticosteroids in tapering doses. Her fever abated over the next 3 days and the skin lesions gradually resolved with postinflammatory hyperpigmentation. Based on the condition arising a few weeks after starting carbamazepine, resolution on withdrawal of carbamazepine and response to steroids, a final diagnosis of neutrophilic eccrine hidradenitis was reached. Author comment: "Causality assessment score was performed using Naranjo’s algorithm and was scored 6 which suggested a probable relationship between the reaction and carbamazepine". Bhanu P, et al. Neutrophilic eccrine hidradenitis: A new culprit-carbamazepine. Indian Journal of Pharmacology 45: 91-92, No. 1, Feb 2013. Available from: URL: http://dx.doi.org/10.4103/0253-7613.106445 - India 803085512 1 Reactions 13 Apr 2013 No. 1447 0114-9954/10/1447-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 1447 - 13 Apr 2013
SCarbamazepine
Neutrophilic eccrine hidradenitis: case reportA 40-year-old woman developed neutrophilic eccrine
hidradenitis while receiving carbamazepine for epilepsy.The woman was admitted to hospital with fever, puffiness of
face, vomiting and skin rash for 5 days. She had been receivingcarbamazepine for 1 month [route and dosage not stated] totreat epilepsy. A dermatological examination revealed multiplenonscaly, dry, round-to-oval, discretely arranged bilaterallynear symmetrical nodules, pustules, vesicles and papules onher hands and forearms. There was mild skin peeling observedover her abdomen and proximal areas of her upper and lowerlimbs. Histological analysis of a skin biopsy from her rightforearm showed a neutrophilic infiltrate surrounding theeccrine glands and sparing the duct. A focal interface vacuolardermatitis was evident. Some histiocytes and scatteredlymphocytes were seen within the dermis.
The woman was started on oral corticosteroids in taperingdoses. Her fever abated over the next 3 days and the skinlesions gradually resolved with postinflammatoryhyperpigmentation. Based on the condition arising a fewweeks after starting carbamazepine, resolution on withdrawalof carbamazepine and response to steroids, a final diagnosis ofneutrophilic eccrine hidradenitis was reached.
Author comment: "Causality assessment score wasperformed using Naranjo’s algorithm and was scored 6 whichsuggested a probable relationship between the reaction andcarbamazepine".Bhanu P, et al. Neutrophilic eccrine hidradenitis: A new culprit-carbamazepine.Indian Journal of Pharmacology 45: 91-92, No. 1, Feb 2013. Available from: URL:http://dx.doi.org/10.4103/0253-7613.106445 - India 803085512
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Reactions 13 Apr 2013 No. 14470114-9954/10/1447-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
