Carbamazepine
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Reactions 1433 - 5 Jan 2013 S Carbamazepine DRESS with reactivation of human herpesvirus 7: case report A 62-year-old man developed drug eruption with eosinophilia and systemic syndrome (DRESS) with human herpesvirus-7 (HHV-7) reactivation while receiving carbamazepine. The man was receiving oral carbamazepine [dosage not stated] for pain after surgery for prostate cancer on 30 June 2004. On 11 July, he developed fever and systemic diffuse erythema and was diagnosed with hepatic dysfunction. He was urgently admitted 3 days later with systemic diffuse erythema, eosinophilia, liver dysfunction and facial oedema. Skin biopsy showed small amounts of eosinophils and nuclear dust with perivascular lymphocytic infiltration with the upper dermis; DRESS was suspected. Carbamazepine was discontinued and the man started receiving prednisolone; his fever and skin eruption gradually improved. Four days after his initial presentation, HHV-7 DNA was found in peripheral blood. Five days after initial presentation, high titres of IgG antibodies to HHV-7 were recorded. HHV-7 DNA became negative 15 days after initial presentation, following remission of the eruption. The man subsequently underwent patch testing, which was positive for carbamazepine after 48 and 72 hours. A drug- induced lymphocyte stimulation test was positive for carbamazepine. Author comment: "Our case took carbamazepine p.o. for 11 days before the onset of the disease. . . diagnostic criteria for DRESS are fulfilled and our patient showed solely HHV-7 reactivation as far as we examined." Morito H, et al. Drug eruption with eosinophilia and systemic syndrome associated with reactivation of human herpesvirus 7, not human herpesvirus 6. Journal of Dermatology 39: 669-70, No. 7, Jul 2012. Available from: URL: http:// dx.doi.org/10.1111/j.1346-8138.2011.01365.x - Japan 803081495 1 Reactions 5 Jan 2013 No. 1433 0114-9954/10/1433-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Carbamazepine
Reactions 1433 - 5 Jan 2013
SCarbamazepine
DRESS with reactivation of human herpesvirus 7:case report
A 62-year-old man developed drug eruption witheosinophilia and systemic syndrome (DRESS) with humanherpesvirus-7 (HHV-7) reactivation while receivingcarbamazepine.
The man was receiving oral carbamazepine [dosage notstated] for pain after surgery for prostate cancer on30 June 2004. On 11 July, he developed fever and systemicdiffuse erythema and was diagnosed with hepatic dysfunction.He was urgently admitted 3 days later with systemic diffuseerythema, eosinophilia, liver dysfunction and facial oedema.Skin biopsy showed small amounts of eosinophils and nucleardust with perivascular lymphocytic infiltration with the upperdermis; DRESS was suspected.
Carbamazepine was discontinued and the man startedreceiving prednisolone; his fever and skin eruption graduallyimproved. Four days after his initial presentation, HHV-7 DNAwas found in peripheral blood. Five days after initialpresentation, high titres of IgG antibodies to HHV-7 wererecorded. HHV-7 DNA became negative 15 days after initialpresentation, following remission of the eruption.
The man subsequently underwent patch testing, which waspositive for carbamazepine after 48 and 72 hours. A drug-induced lymphocyte stimulation test was positive forcarbamazepine.
Author comment: "Our case took carbamazepine p.o. for11 days before the onset of the disease. . . diagnostic criteriafor DRESS are fulfilled and our patient showed solely HHV-7reactivation as far as we examined."Morito H, et al. Drug eruption with eosinophilia and systemic syndrome associatedwith reactivation of human herpesvirus 7, not human herpesvirus 6. Journal ofDermatology 39: 669-70, No. 7, Jul 2012. Available from: URL: http://dx.doi.org/10.1111/j.1346-8138.2011.01365.x - Japan 803081495
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Reactions 5 Jan 2013 No. 14330114-9954/10/1433-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
