Carbamazepine
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Reactions 1348 - 23 Apr 2011 S Carbamazepine Drug hypersensitivity in an elderly patient: case report A 72-year-old woman developed drug-induced hypersensitivity syndrome during treatment with carbamazepine. The woman started receiving oral carbamazepine [Amizepin] 200mg three times daily for sensory axonal polyneuropathy due to influenza virus vaccine in December 2009. On 4 January 2010, she was admitted following the onset of a maculopapular rash over her entire body and fever. On admission, she had elevated levels of CRP and her ESR was high. Laboratory tests found signs of liver cell damage, and a urine analysis revealed erythrocyturia. A skin biopsy revealed chronic inflammatory infiltration in the layer of the dermis around the vessels and around appendages, consisting mainly of small lymphocytes, plasma cells, neutrophilic granulocytes, small numbers of melanophages and a few eosinophils. Carbamazepine was discontinued, and the woman received systemic corticosteroid and antihistamine therapy which led to remission of the skin eruptions and the disappearance of her general systemic symptoms. Author comment: The timing of the onset of symptoms following commencement of carbamazepine (at around 4 weeks) is also characteristic, and would seem to corroborate the presence of a cause-and-effect relationship with use of this drug, which is one of those most often responsible for the occurrence of drug-induced hypersensitivity syndrome. Gomulka K, et al. Drug-induced hypersensitivity syndrome--a literature review and the case report. Pneumonologia I Alergologia Polska 79: 52-6, No. 1, Jan 2011 [Polish; summarised from a translation] - Poland 803053386 1 Reactions 23 Apr 2011 No. 1348 0114-9954/10/1348-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine
Reactions 1348 - 23 Apr 2011
SCarbamazepine
Drug hypersensitivity in an elderly patient: casereport
A 72-year-old woman developed drug-inducedhypersensitivity syndrome during treatment withcarbamazepine.
The woman started receiving oral carbamazepine[Amizepin] 200mg three times daily for sensory axonalpolyneuropathy due to influenza virus vaccine inDecember 2009. On 4 January 2010, she was admittedfollowing the onset of a maculopapular rash over her entirebody and fever. On admission, she had elevated levels ofCRP and her ESR was high. Laboratory tests found signs ofliver cell damage, and a urine analysis revealederythrocyturia. A skin biopsy revealed chronicinflammatory infiltration in the layer of the dermis aroundthe vessels and around appendages, consisting mainly ofsmall lymphocytes, plasma cells, neutrophilicgranulocytes, small numbers of melanophages and a feweosinophils.
Carbamazepine was discontinued, and the womanreceived systemic corticosteroid and antihistamine therapywhich led to remission of the skin eruptions and thedisappearance of her general systemic symptoms.
Author comment: The timing of the onset of symptomsfollowing commencement of carbamazepine (at around 4weeks) is also characteristic, and would seem to corroboratethe presence of a cause-and-effect relationship with use ofthis drug, which is one of those most often responsible forthe occurrence of drug-induced hypersensitivity syndrome.Gomulka K, et al. Drug-induced hypersensitivity syndrome--a literature review andthe case report. Pneumonologia I Alergologia Polska 79: 52-6, No. 1, Jan 2011[Polish; summarised from a translation] - Poland 803053386
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Reactions 23 Apr 2011 No. 13480114-9954/10/1348-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
