Carbamazepine
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Reactions 1393 - 17 Mar 2012 S Carbamazepine Generalised maculopapular exanthema: 3 case reports Three paediatric patients aged 9–18 years developed generalised maculopapular exanthema while receiving treatment with carbamazepine [dosages and routes not stated]. A 13-year-old girl with right temporal ganglioma developed a generalised itching erythema after 7 days of treatment with carbamazepine. The other two patients, an 18-year-old boy with a history of epilepsy and a 9-year-old girl with cortical dysplasia associated with partial epilepsy, developed a generalised maculopapular erythema or a maculopapular exanthema after 14 days of treatment with carbamazepine. All patients were hospitalised. Skin tests performed with carbamazepine and oxcarbazepine were negative for all three patients. An oral tolerance test with oxcarbazepine at different dilutions was tolerated by all three patients, and they were then treated with oxcarbazepine after discharge, which was well tolerated. Colagiovanni A, et al. Carbamazepine hypersensitivity and alternative anticonvulsant. Allergy 66 (Suppl. 94): 380, Jun 2011. Available from: URL: http:/ /dx.doi.org/10.1111/j.1398-9995.2011.02607.x [abstract] - Italy 803067791 1 Reactions 17 Mar 2012 No. 1393 0114-9954/10/1393-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine
Reactions 1393 - 17 Mar 2012
SCarbamazepine
Generalised maculopapular exanthema: 3 casereports
Three paediatric patients aged 9–18 years developedgeneralised maculopapular exanthema while receivingtreatment with carbamazepine [dosages and routes notstated].
A 13-year-old girl with right temporal gangliomadeveloped a generalised itching erythema after 7 days oftreatment with carbamazepine. The other two patients, an18-year-old boy with a history of epilepsy and a 9-year-oldgirl with cortical dysplasia associated with partial epilepsy,developed a generalised maculopapular erythema or amaculopapular exanthema after 14 days of treatment withcarbamazepine.
All patients were hospitalised. Skin tests performed withcarbamazepine and oxcarbazepine were negative for allthree patients. An oral tolerance test with oxcarbazepine atdifferent dilutions was tolerated by all three patients, andthey were then treated with oxcarbazepine after discharge,which was well tolerated.Colagiovanni A, et al. Carbamazepine hypersensitivity and alternativeanticonvulsant. Allergy 66 (Suppl. 94): 380, Jun 2011. Available from: URL: http://dx.doi.org/10.1111/j.1398-9995.2011.02607.x [abstract] - Italy 803067791
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Reactions 17 Mar 2012 No. 13930114-9954/10/1393-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
