Carbamazepine
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Reactions 1300 - 8 May 2010 S Carbamazepine Acute lymphocytic colitis in an elderly patient: case report A 77-year-old man was diagnosed with acute lymphocytic colitis during treatment with carbamazepine for trigeminal neuralgia. The man presented in May 2007 with a 15-day history of diarrhoea, with two watery, painless, nonbloody stools per day. Two months prior to diarrhoea onset, he had started treatment with controlled-release carbamazepine 200 mg/day. A colonoscopy showed discreet abnormalities, which were diffuse and unspecific. Parasite and ova stool tests were negative. Serum albumin, iron levels, CRP levels, ESR and full blood count tests were normal. Carbamazepine was discontinued and within 10 days the man was asymptomatic. One year later, a colonoscopy showed normalisation. It was decided to not reintroduce carbamazepine. Author comment: According to the criteria of B´ egaud et al., the sudden onset of the patient’s diarrhoea two months after he started treatment with carbamazepine suggests that this agent was the causative agent. The return of normal bowel habits ten days after cessation of treatment is also an indication for a causal relationship. This case has a temporal- relationship score of C3, a symptom score of S3 and a global causality score of I4 (very likely). Maroy B. Acute lymphocytic colitis due to carbamazepine. [French]. Gastroenterologie Clinique et Biologique 34: 155-156, No. 2, Feb 2010. Available from: URL: http://dx.doi.org/10.1016/j.gcb.2009.09.005 [French; summarised from a translation] - France 803013743 1 Reactions 8 May 2010 No. 1300 0114-9954/10/1300-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Carbamazepine
Reactions 1300 - 8 May 2010
SCarbamazepine
Acute lymphocytic colitis in an elderly patient:case report
A 77-year-old man was diagnosed with acutelymphocytic colitis during treatment with carbamazepinefor trigeminal neuralgia.
The man presented in May 2007 with a 15-day history ofdiarrhoea, with two watery, painless, nonbloody stools perday. Two months prior to diarrhoea onset, he had startedtreatment with controlled-release carbamazepine200 mg/day. A colonoscopy showed discreetabnormalities, which were diffuse and unspecific. Parasiteand ova stool tests were negative. Serum albumin, ironlevels, CRP levels, ESR and full blood count tests werenormal.
Carbamazepine was discontinued and within 10 days theman was asymptomatic. One year later, a colonoscopyshowed normalisation. It was decided to not reintroducecarbamazepine.
Author comment: According to the criteria of Begaud etal., the sudden onset of the patient’s diarrhoea two monthsafter he started treatment with carbamazepine suggests thatthis agent was the causative agent. The return of normalbowel habits ten days after cessation of treatment is also anindication for a causal relationship. This case has a temporal-relationship score of C3, a symptom score of S3 and a globalcausality score of I4 (very likely).Maroy B. Acute lymphocytic colitis due to carbamazepine. [French].Gastroenterologie Clinique et Biologique 34: 155-156, No. 2, Feb 2010. Availablefrom: URL: http://dx.doi.org/10.1016/j.gcb.2009.09.005 [French; summarised froma translation] - France 803013743
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Reactions 8 May 2010 No. 13000114-9954/10/1300-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
