Carbamazepine
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Reactions 1478, p13 - 16 Nov 2013 S Carbamazepine Stevens-Johnson syndrome in a child: case report A 9-year-old girl developed Stevens-Johnson syndrome following treatment with carbamazepine [Tegretol] for episodic headaches. The girl was hospitalised with fever, cough and generalised skin eruption; the fever developed 3 weeks after carbamazepine was initiated for severe episodic headaches [route and dosage not stated]. She reported progressive dysphagia, photophobia and dysuria; agitation was noted. Pyrexia, significant conjunctivitis and small vesicles located to oral and nasal mucosa were noted, on examination. An erythematous eruption coalesced predominantly on the trunk with numerous vesicles and a few necrotic lesions; vesicles were also noted on her genitalia. Her total WBC count was 11 × 10 9 /L with a CRP value of 31 mg/L; mild elevation of serum transaminases were also noted. Carbamazepine was discontinued; supportive therapy was initiated, and dexamethasone and cefazoline were administered. The girl stabilised after approximately 48 hours, and she returned home after 15 days with instructions to avoid future carbamazepine treatment. Author comment: "Antiepileptics such as phenytoin, phenobarbital, and carbamazepine play an important role in the development of drug-induced serious skin reactions such as SJS [Stevens-Johnson syndrome] and TEN." Muci M, et al. Stevens-Johnson syndrome: Case report. Paediatria Croatica 57: 268-270, No. 3, Sep 2013 - Albania 803095588 1 Reactions 16 Nov 2013 No. 1478 0114-9954/13/1478-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
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Transcript of Carbamazepine
Reactions 1478, p13 - 16 Nov 2013
SCarbamazepine
Stevens-Johnson syndrome in a child: case reportA 9-year-old girl developed Stevens-Johnson syndrome
following treatment with carbamazepine [Tegretol] forepisodic headaches.
The girl was hospitalised with fever, cough and generalisedskin eruption; the fever developed 3 weeks aftercarbamazepine was initiated for severe episodic headaches[route and dosage not stated]. She reported progressivedysphagia, photophobia and dysuria; agitation was noted.Pyrexia, significant conjunctivitis and small vesicles located tooral and nasal mucosa were noted, on examination. Anerythematous eruption coalesced predominantly on the trunkwith numerous vesicles and a few necrotic lesions; vesicleswere also noted on her genitalia. Her total WBC count was11 × 109/L with a CRP value of 31 mg/L; mild elevation ofserum transaminases were also noted.
Carbamazepine was discontinued; supportive therapy wasinitiated, and dexamethasone and cefazoline wereadministered. The girl stabilised after approximately 48 hours,and she returned home after 15 days with instructions to avoidfuture carbamazepine treatment.
Author comment: "Antiepileptics such as phenytoin,phenobarbital, and carbamazepine play an important role inthe development of drug-induced serious skin reactions suchas SJS [Stevens-Johnson syndrome] and TEN."Muci M, et al. Stevens-Johnson syndrome: Case report. Paediatria Croatica 57:268-270, No. 3, Sep 2013 - Albania 803095588
1
Reactions 16 Nov 2013 No. 14780114-9954/13/1478-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
