Benazepril
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Reactions 790 - 26 Feb 2000 S Benazepril Angioneurotic oedema in an elderly patient: case report A 73-year-old woman developed acute angioneurotic oedema after she had been treated with benazepril 30mg twice daily for approximately 27 months for hypertension. The patient was admitted to an emergency department with respiratory distress and lethargy. Her tongue was protruding and filled her entire mouth. Her BP was 189/97mm Hg, her HR was 67 beats/min and her respiratory rate was 24 breaths/min. She was treated with IV methylprednisolone, IV diphenydramine and famotidine, with no improvement. A neck x-ray showed severe oedema of her tongue and epiglottis. Approximately 3 hours after the woman had first developed angioneurotic oedema, she underwent a tracheotomy and was mechanically ventilated. She was administered dexamethasone, diphenhydramine, famotidine and hydralazine. Benazepril was discontinued. The patient was taken off the ventilator on hospital day 2, but her tongue was still enlarged. On hospital day 15, her tongue swelling had resolved, but she found it difficult to swallow. [Patient outcome not stated.] Author comment: ‘As the use of ACE inhibitor therapy continues to expand, clinicians must appreciate the fact that angioedema is a known adverse effect of this class and may occur anytime during therapy.’ Maliekal J, et al. Acute angioedema associated with long-term benazepril therapy. Journal of Pharmacy Technology 15: 208-211, Nov-Dec 1999 - USA 800813434 1 Reactions 26 Feb 2000 No. 790 0114-9954/10/0790-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Benazepril
Reactions 790 - 26 Feb 2000
SBenazepril
Angioneurotic oedema in an elderly patient: casereport
A 73-year-old woman developed acute angioneuroticoedema after she had been treated with benazepril 30mg twicedaily for approximately 27 months for hypertension.
The patient was admitted to an emergency department withrespiratory distress and lethargy. Her tongue was protrudingand filled her entire mouth. Her BP was 189/97mm Hg, her HRwas 67 beats/min and her respiratory rate was 24 breaths/min.She was treated with IV methylprednisolone, IVdiphenydramine and famotidine, with no improvement. Aneck x-ray showed severe oedema of her tongue andepiglottis.
Approximately 3 hours after the woman had first developedangioneurotic oedema, she underwent a tracheotomy and wasmechanically ventilated. She was administereddexamethasone, diphenhydramine, famotidine andhydralazine. Benazepril was discontinued. The patient wastaken off the ventilator on hospital day 2, but her tongue wasstill enlarged. On hospital day 15, her tongue swelling hadresolved, but she found it difficult to swallow. [Patientoutcome not stated.]
Author comment: ‘As the use of ACE inhibitor therapycontinues to expand, clinicians must appreciate the fact thatangioedema is a known adverse effect of this class and mayoccur anytime during therapy.’Maliekal J, et al. Acute angioedema associated with long-term benazepril therapy.Journal of Pharmacy Technology 15: 208-211, Nov-Dec 1999 - USA 800813434
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Reactions 26 Feb 2000 No. 7900114-9954/10/0790-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
