Benazepril
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Reactions 1384 - 14 Jan 2012 S Benazepril Life-threatening angioedema in an elderly patient: case report A 65-year-old man developed life-threatening angioedema following treatment with benazepril. The man had a history of intermittent oedema of the face, eyes and lips, that was alleviated by hydroxyzine and prednisone. He was receiving benazepril for hypertension [dosage and route not stated]. Two weeks following prednisone withdrawal, he developed angioedema, dyspnoea and an erythematous rash [duration of treatment to reaction onset not stated]. Benazepril was discontinued, and the man was intubated. He received diphenhydramine, epinephrine [adrenaline] and methylprednisolone, and his rash and angioedema resolved. On follow up, he presented with facial angioedema and urticarial lesions. He received famotidine, prednisone, cetirizine and diphenhydramine [outcome not clearly stated]. Tests revealed an IgE receptor antibody titre of 12.4%, and a serum IgE level of 199 IU/mL. Author comment: "[O]ur patient had underlying chronic autoimmune urticaria with angioedema, which in the setting of [ACE inhibitor] use precipitated a life-threatening reaction." Kleva A, et al. Life-Threatening Angioedema in the Setting of Chronic Autoimmune Urticaria and Ace-Inhibitor use. 2011 Annual Meeting of the American College of Allergy, Asthma and Immunology : abstr. P150, 3 Nov 2011. Available from: URL: http://www.acaai.org - USA 803065483 1 Reactions 14 Jan 2012 No. 1384 0114-9954/10/1384-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Benazepril
Reactions 1384 - 14 Jan 2012
SBenazepril
Life-threatening angioedema in an elderly patient:case report
A 65-year-old man developed life-threateningangioedema following treatment with benazepril.
The man had a history of intermittent oedema of the face,eyes and lips, that was alleviated by hydroxyzine andprednisone. He was receiving benazepril for hypertension[dosage and route not stated]. Two weeks followingprednisone withdrawal, he developed angioedema,dyspnoea and an erythematous rash [duration of treatmentto reaction onset not stated].
Benazepril was discontinued, and the man wasintubated. He received diphenhydramine, epinephrine[adrenaline] and methylprednisolone, and his rash andangioedema resolved. On follow up, he presented withfacial angioedema and urticarial lesions. He receivedfamotidine, prednisone, cetirizine and diphenhydramine[outcome not clearly stated]. Tests revealed an IgE receptorantibody titre of 12.4%, and a serum IgE level of 199 IU/mL.
Author comment: "[O]ur patient had underlying chronicautoimmune urticaria with angioedema, which in the settingof [ACE inhibitor] use precipitated a life-threatening reaction."Kleva A, et al. Life-Threatening Angioedema in the Setting of ChronicAutoimmune Urticaria and Ace-Inhibitor use. 2011 Annual Meeting of theAmerican College of Allergy, Asthma and Immunology : abstr. P150, 3 Nov 2011.Available from: URL: http://www.acaai.org - USA 803065483
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Reactions 14 Jan 2012 No. 13840114-9954/10/1384-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
