Antineoplastics
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Reactions 462 - 31 Jul 1993 Antineoplastics Lack of dysmorphogenesis: incidence study The risk of having a child with congenital abnormalities is not increased in parents diagnosed with cancer prior to conception, when compared with the general population, regardless of whether they have been treated with antineoplastics/radiotherapy or not. This was the conclusion of a Canadian case-control study of 45 200 case mothers and 41 158 case fathers of children with a congenital abnormality, and their matched controls who had children without such abnormalities. Comparison of the mothers in the 2 groups revealed a history of cancer in 54 case and 52 control mothers (relative risk 1.04). Comparison of the fathers in each group identified 61 case and 65 control fathers (relative risk 0.9). No significant increase in the relative risk of any subgroup of congenital abnormalities was seen in the case groups. Dodds L, et al. Case-control study of congenital anomalies in children of cancer patients. BMJ 307: 164-168, 17 Jul 1993 - Canada 800208168 1 Reactions 31 Jul 1993 No. 462 0114-9954/10/0462-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 462 - 31 Jul 1993
Antineoplastics
Lack of dysmorphogenesis: incidence studyThe risk of having a child with congenital abnormalities is
not increased in parents diagnosed with cancer prior toconception, when compared with the general population,regardless of whether they have been treated withantineoplastics/radiotherapy or not.
This was the conclusion of a Canadian case-control study of45 200 case mothers and 41 158 case fathers of children with acongenital abnormality, and their matched controls who hadchildren without such abnormalities.
Comparison of the mothers in the 2 groups revealed ahistory of cancer in 54 case and 52 control mothers (relativerisk 1.04). Comparison of the fathers in each group identified61 case and 65 control fathers (relative risk 0.9). No significantincrease in the relative risk of any subgroup of congenitalabnormalities was seen in the case groups.Dodds L, et al. Case-control study of congenital anomalies in children of cancerpatients. BMJ 307: 164-168, 17 Jul 1993 - Canada 800208168
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Reactions 31 Jul 1993 No. 4620114-9954/10/0462-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
