Antineoplastics
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Reactions 463 - 7 Aug 1993 Antineoplastics Thymic hyperplasia: 2 case reports Thymic masses were detected in 2 patients treated with antineoplastic therapy for Hodgkin’s disease. Both were subsequently found to be composed of normal thymic tissue. After the first patient, a 19-year-old man, completed treatment with 6 cycles of an antineoplastic regimen comprising doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD), a CT scan showed a normal thymus. Three months later, a second CT scan revealed an enlarged thymus, but biopsies of this showed thymic hyperplasia only. Eight months after completion of treatment, the thymus was still enlarged. At 27-months’ follow-up, the patient remained well and disease-free. The second patient, a 22-year-old man was treated with 6 cycles of an antineoplastic regimen including chlormethine, vincristine, procarbazine and prednisone (MOPP-ABV hybrid). After 4 cycles of therapy, a CT scan showed a soft tissue mass in the superior mediastinal mass. A biopsy showed only benign mesothelial cells. The mass enlarged slightly over the following month, but a further biopsy revealed a normal thymus gland. 36 months later, the superior mediastinal mass is unchanged in size and the patient remains in remission. Author comment: Thymic hyperplasia was documented by CT scan alone in 3 patients with malignancies other than lymphoma after treatment with intensive antineoplastic therapy. Simmonds P, et al. Thymic hyperplasia in adults following chemotherapy for malignancy. Australian and New Zealand Journal of Medicine 23: 264-267, Jun 1993 - Australia 800210199 1 Reactions 7 Aug 1993 No. 463 0114-9954/10/0463-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 463 - 7 Aug 1993
Antineoplastics
Thymic hyperplasia: 2 case reportsThymic masses were detected in 2 patients treated with
antineoplastic therapy for Hodgkin’s disease. Both weresubsequently found to be composed of normal thymic tissue.
After the first patient, a 19-year-old man, completedtreatment with 6 cycles of an antineoplastic regimencomprising doxorubicin, bleomycin, vinblastine anddacarbazine (ABVD), a CT scan showed a normal thymus.Three months later, a second CT scan revealed an enlargedthymus, but biopsies of this showed thymic hyperplasia only.Eight months after completion of treatment, the thymus wasstill enlarged. At 27-months’ follow-up, the patient remainedwell and disease-free.
The second patient, a 22-year-old man was treated with 6cycles of an antineoplastic regimen including chlormethine,vincristine, procarbazine and prednisone (MOPP-ABV hybrid).After 4 cycles of therapy, a CT scan showed a soft tissue massin the superior mediastinal mass. A biopsy showed only benignmesothelial cells. The mass enlarged slightly over the followingmonth, but a further biopsy revealed a normal thymus gland.36 months later, the superior mediastinal mass is unchangedin size and the patient remains in remission.
Author comment: Thymic hyperplasia was documented byCT scan alone in 3 patients with malignancies other thanlymphoma after treatment with intensive antineoplastictherapy.Simmonds P, et al. Thymic hyperplasia in adults following chemotherapy formalignancy. Australian and New Zealand Journal of Medicine 23: 264-267, Jun1993 - Australia 800210199
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Reactions 7 Aug 1993 No. 4630114-9954/10/0463-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
