Antineoplastics
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Reactions 411 - 25 Jul 1992 S Antineoplastics Acceleration of retinitis pigmentosa: case report A 53-year-old man who had been deaf and mute since birth developed retinitis pigmentosa and became blind following 8 courses of therapy with cyclophosphamide, doxorubicin, vincristine and prednisone over 6 months for lymphoma. The patient appeared to have normal vision at the start of treatment but was blind 4 months after completing treatment. Author comment: The retinitis pigmentosa was thought to be related to Usher’s syndrome, a condition associated with sensorineural deafness at birth, and not to the patient’s cancer. However, the rapid deterioration in vision seen in this patient is unusual in Usher’s syndrome. ’The use of DNA-damaging cytotoxic chemotherapy may have accelerated RP retinitis pigmentosa in our patient.’ Blanchet P, et al. Case report: retinitis pigmentosa following cytotoxic chemotherapy in Usher’s syndrome. American Journal of the Medical Sciences 303: 319-320, May 1992 - USA 800142681 1 Reactions 25 Jul 1992 No. 411 0114-9954/10/0411-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 411 - 25 Jul 1992
SAntineoplastics
Acceleration of retinitis pigmentosa: case reportA 53-year-old man who had been deaf and mute since birth
developed retinitis pigmentosa and became blind following 8courses of therapy with cyclophosphamide, doxorubicin,vincristine and prednisone over 6 months for lymphoma.
The patient appeared to have normal vision at the start oftreatment but was blind 4 months after completing treatment.
Author comment: The retinitis pigmentosa was thought tobe related to Usher’s syndrome, a condition associated withsensorineural deafness at birth, and not to the patient’s cancer.However, the rapid deterioration in vision seen in this patientis unusual in Usher’s syndrome. ’The use of DNA-damagingcytotoxic chemotherapy may have accelerated RP retinitispigmentosa in our patient.’Blanchet P, et al. Case report: retinitis pigmentosa following cytotoxicchemotherapy in Usher’s syndrome. American Journal of the Medical Sciences303: 319-320, May 1992 - USA 800142681
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Reactions 25 Jul 1992 No. 4110114-9954/10/0411-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
