Antineoplastics
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Reactions 396 - 11 Apr 1992 S Antineoplastics Cerebrovascular disorders: case report After 5 days’ treatment with IV fluorouracil, cisplatin, and bleomycin, a 59-year-old man with advanced oesophageal carcinoma developed an acute confusional state, motor aphasia and visual disturbances. A CT scan of the brain 48 hours after the onset of symptoms was normal; however, a repeat scan 6 days later showed a left occipital posterior infarction. The patient’s neurological status gradually returned to normal although he had persistent visual problems. Cisplatin- based antineoplastic therapy was discontinued and palliative radiotherapy was administered. The authors could not definitely implicate the patient’s antineoplastic therapy as the cause of the cerebrovascular accident but they do suggest that, if this was the case, then previous epirubicin therapy may also have contributed by inducing a hypercoagulable state Gandia D, et al. Cerebrovascular accident associated with chemotherapy for oesophageal carcinoma. European Journal of Cancer 28: 245, Jan 1992 - France 800126316 1 Reactions 11 Apr 1992 No. 396 0114-9954/10/0396-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 396 - 11 Apr 1992
SAntineoplastics
Cerebrovascular disorders: case reportAfter 5 days’ treatment with IV fluorouracil, cisplatin, and
bleomycin, a 59-year-old man with advanced oesophagealcarcinoma developed an acute confusional state, motoraphasia and visual disturbances. A CT scan of the brain 48hours after the onset of symptoms was normal; however, arepeat scan 6 days later showed a left occipital posteriorinfarction.
The patient’s neurological status gradually returned tonormal although he had persistent visual problems. Cisplatin-based antineoplastic therapy was discontinued and palliativeradiotherapy was administered.
The authors could not definitely implicate the patient’santineoplastic therapy as the cause of the cerebrovascularaccident but they do suggest that, if this was the case, thenprevious epirubicin therapy may also have contributed byinducing a hypercoagulable stateGandia D, et al. Cerebrovascular accident associated with chemotherapy foroesophageal carcinoma. European Journal of Cancer 28: 245, Jan 1992 -France 800126316
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Reactions 11 Apr 1992 No. 3960114-9954/10/0396-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
