Antineoplastics
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Antineoplastics Oral mucosal lesions: incidence study The following patient groups were studied in an attempt to determine the incidence of oral mucosal lesions associated with antineoplastic therapy: 13 men and 13 women aged 5-7 4 (median 49) years with leukaemia or lymphoma in first presentation or relapse (Group A); 20 acute patients aged 7-84 (median 65) years who had been hospitalised for 1-3 days (Group B); 20 chronic patients aged 34-96 (median 86) years who had been hospitalised for > 2 months (Group C); 20 patients aged 14-75 (median 45) years receiving parenteral antibiotics for ;;;. 6 days (Group 0). No patient in groups B or C received antibiotics. Patients in group A received cytotoxic therapy after day 2 of hospitalisation, including daunorubicin, cytarabine and thioguanine (acute myeloblastic leukaemia; n = 16) and methotrexate, angular cheilitis, 5 had ulcerations related to dentures and 3 had severe gingivitis. Two group B and 3 group D patients had small ulcers. Nine patients in group A had candidiasis- like changes, 1 before, 3 during and 5 after therapy. One group C and 2 group D patients had similar changes. There were no statistically significant differences in the occurrence of oral mucosal lesions between pat1ents w1th different forms of leukaemia/ lymphoma Platelet counts were significantly lower in group A patients with haemorrhages vs those without, during (0.1% probability) and after (2.5% probability) treatment, and granulocyte counts were significantly lower in group A patients with ulcers vs those without. after therapy (2 5% probability). Cytotox1c drugs may have a direct effect on the mucosa in addition to myelosuppressive and immunosuppressive effects. Wahl1n TB. Matsson L Scand1nav1an Journal of Dental Research 96 128-136. Apr 1988 sas; 4 REACTIONS"' 11 June 1988 0157-7271/88/0611-0004/0$01.00/0 © ADIS Press
Transcript of Antineoplastics
Antineoplastics Oral mucosal lesions: incidence study
The following patient groups were studied in an attempt to determine the incidence of oral mucosal lesions associated with antineoplastic therapy: 13 men and 13 women aged 5-7 4 (median 49) years with leukaemia or lymphoma in first presentation or relapse (Group A); 20 acute patients aged 7-84 (median 65) years who had been hospitalised for 1-3 days (Group B); 20 chronic patients aged 34-96 (median 86) years who had been hospitalised for > 2 months (Group C); 20 patients aged 14-75 (median 45) years receiving parenteral antibiotics for ;;;. 6 days (Group 0). No patient in groups B or C received antibiotics. Patients in group A received cytotoxic therapy after day 2 of hospitalisation, including daunorubicin, cytarabine and thioguanine (acute myeloblastic leukaemia; n = 16) and methotrexate, angular cheilitis, 5 had ulcerations related to dentures and 3 had severe gingivitis. Two group B and 3 group D patients had small ulcers. Nine patients in group A had candidiasislike changes, 1 before, 3 during and 5 after therapy. One group C and 2 group D patients had similar changes. There were no statistically significant differences in the occurrence of oral mucosal lesions between pat1ents w1th different forms of leukaemia/ lymphoma Platelet counts were significantly lower in group A patients with haemorrhages vs those without, during (0.1% probability) and after (2.5% probability) treatment, and granulocyte counts were significantly lower in group A patients with ulcers vs those without. after therapy (2 5% probability).
Cytotox1c drugs may have a direct effect on the mucosa in addition to myelosuppressive and immunosuppressive effects. Wahl1n TB. Matsson L Scand1nav1an Journal of Dental Research 96 128-136. Apr 1988 sas;
4 REACTIONS"' 11 June 1988 0157-7271/88/0611-0004/0$01.00/0 © ADIS Press
