Antineoplastics
1
Reactions 1325 - 30 Oct 2010 S Antineoplastics Hepatic nodular regenerative hyperplasia? in an elderly patient: case report A 72-year-old man with low-grade follicular cell lymphoma developed nodular regenerative hyperplasia of the liver following CHOP * chemotherapy [dosage and route not stated]. Approximately 5 months after receiving CHOP chemotherapy, the man developed ascites; a high serum- ascites gradient consistent with portal hypertension, and a low LDH, was revealed by a large volume paracentesis. Flow cytometry showed no trace of lymphoma cells. Liver biopsy showed hepatic changes suggestive of nodular regenerative hyperplasia with no associated fibrosis, and an elevated hepatic venous pressure gradient of 24mm Hg. Increasing doses of diuretics failed to resolve the man’s ascites. An oesophagogastroduodenoscopy revealed extensive oesophageal varices with red wale signs. His hepatic venous pressure gradient reduced to 13mm Hg, with complete resolution of his ascites, following insertion of a transjugular intrahepatic portosystemic shunt. * CHOP comprises cyclophosphamide, vincristine, doxorubicin and either prednisone or prednisolone. Ricketts P, et al. Nodular Regenerative Hyperplasia Treated with TIPS. 75th Annual Scientific Meeting of the American College of Gastroenterology : abstr. P611, 15 Oct 2010. Available from: URL: http://www.acg.gi.org - USA 803043061 1 Reactions 30 Oct 2010 No. 1325 0114-9954/10/1325-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1325 - 30 Oct 2010
SAntineoplastics
Hepatic nodular regenerative hyperplasia? in anelderly patient: case report
A 72-year-old man with low-grade follicular celllymphoma developed nodular regenerative hyperplasia ofthe liver following CHOP* chemotherapy [dosage and routenot stated].
Approximately 5 months after receiving CHOPchemotherapy, the man developed ascites; a high serum-ascites gradient consistent with portal hypertension, and alow LDH, was revealed by a large volume paracentesis.Flow cytometry showed no trace of lymphoma cells. Liverbiopsy showed hepatic changes suggestive of nodularregenerative hyperplasia with no associated fibrosis, and anelevated hepatic venous pressure gradient of 24mm Hg.
Increasing doses of diuretics failed to resolve the man’sascites. An oesophagogastroduodenoscopy revealedextensive oesophageal varices with red wale signs. Hishepatic venous pressure gradient reduced to 13mm Hg,with complete resolution of his ascites, following insertionof a transjugular intrahepatic portosystemic shunt.
* CHOP comprises cyclophosphamide, vincristine, doxorubicinand either prednisone or prednisolone.
Ricketts P, et al. Nodular Regenerative Hyperplasia Treated with TIPS. 75thAnnual Scientific Meeting of the American College of Gastroenterology : abstr.P611, 15 Oct 2010. Available from: URL: http://www.acg.gi.org -USA 803043061
1
Reactions 30 Oct 2010 No. 13250114-9954/10/1325-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
