Antineoplastics
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Reactions 1410 - 14 Jul 2012 S Antineoplastics Various toxicities in paediatric patients: 2 case reports Two patients with stage IV neuroblastoma developed various toxicities, including mucositis, gastrointestinal bleeding, hypertension and intracranial bleeding, after receiving iobenguane, carboplatin, melphalan and etoposide [routes not stated]. A 9-month-old girl received six courses of cyclophosphamide, vincristine, etoposide, cisplatin, dacarbazine, ifosfamide and doxorubicin and underwent incomplete resection of an adrenal mass. Prior to bone marrow transplantation, she received a conditioning regimen that consisted of iobenguane 100mCi (10 mCi/kg) on day -21, melphalan 45 mg/m 2 /day on days -8 to -5, etoposide 200 mg/m 2 /day [days of administration not clearly stated] and carboplatin 300 mg/m 2 /day on days -5 to -2. Grade 4 mucositis and massive GI bleeding were observed on day +15 and she died on day +18. An 8-year-old girl received six courses of the same regimen as the previous patient, as well as postoperative radiotherapy for a residual adrenal mass. As conditioning therapy for bone marrow transplantation, she received the same regimen, including iobenguane 100mCi (3.1 mCi/kg) on day -21. Grade 1 graft-versus-host disease was diagnosed on day +7. She experienced acute hypertension and intracranial bleeding on day +25 and died on day +31. Author comment: "Although mucositis and myeloablation was not observed with [iobenguane] as a single agent, combination therapies with drugs at myeloablative doses may increase toxicity. " Kesik V, et al. 131I-metaiodobenzylguanidine conditioning regimen in children with neuroblastoma undergoing autologous peripheral stem cell transplantation. Bone Marrow Transplantation 47 (Suppl. 1): S380, Apr 2012. Available from: URL: http://dx.doi.org/10.1038/bmt.2012.37 [abstract] - Turkey 803072462 1 Reactions 14 Jul 2012 No. 1410 0114-9954/10/1410-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1410 - 14 Jul 2012
SAntineoplastics
Various toxicities in paediatric patients: 2 casereports
Two patients with stage IV neuroblastoma developedvarious toxicities, including mucositis, gastrointestinalbleeding, hypertension and intracranial bleeding, afterreceiving iobenguane, carboplatin, melphalan andetoposide [routes not stated].
A 9-month-old girl received six courses ofcyclophosphamide, vincristine, etoposide, cisplatin,dacarbazine, ifosfamide and doxorubicin and underwentincomplete resection of an adrenal mass. Prior to bonemarrow transplantation, she received a conditioningregimen that consisted of iobenguane 100mCi (10 mCi/kg)on day -21, melphalan 45 mg/m2/day on days -8 to -5,etoposide 200 mg/m2/day [days of administration notclearly stated] and carboplatin 300 mg/m2/day on days -5to -2. Grade 4 mucositis and massive GI bleeding wereobserved on day +15 and she died on day +18.
An 8-year-old girl received six courses of the sameregimen as the previous patient, as well as postoperativeradiotherapy for a residual adrenal mass. As conditioningtherapy for bone marrow transplantation, she received thesame regimen, including iobenguane 100mCi (3.1 mCi/kg)on day -21. Grade 1 graft-versus-host disease wasdiagnosed on day +7. She experienced acute hypertensionand intracranial bleeding on day +25 and died on day +31.
Author comment: "Although mucositis and myeloablationwas not observed with [iobenguane] as a single agent,combination therapies with drugs at myeloablative doses mayincrease toxicity. "Kesik V, et al. 131I-metaiodobenzylguanidine conditioning regimen in childrenwith neuroblastoma undergoing autologous peripheral stem cell transplantation.Bone Marrow Transplantation 47 (Suppl. 1): S380, Apr 2012. Available from:URL: http://dx.doi.org/10.1038/bmt.2012.37 [abstract] - Turkey 803072462
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Reactions 14 Jul 2012 No. 14100114-9954/10/1410-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
