Antineoplastics
1
Reactions 1400 - 5 May 2012 S Antineoplastics Parvovirus B19 infection-related acute hepatitis: case report A 49-year-old woman was diagnosed with intestinal diffuse large B-cell lymphoma. She received one cycle of CEOP chemotherapy comprising cyclophosphamide, vincristine, epirubicin and dexamethasone, followed by five cycles of CEOP with rituximab [routes and dosages not stated]. Following chemotherapy, she developed acute hepatitis with persistent leucopenia and thrombocytopenia. Liver biopsy showed acute hepatitis, and parvovirus B19 was found in some hepatocytes on immunohistochemistry. Parvovirus B19 infection was confirmed by PCR [duration of treatment to reaction onset not stated]. Eight months after the onset of hepatitis, her liver function recovered spontaneously. Author comment: "For patients treated with rituximab- based regimens, we suggest a high degree of clinical suspicion for hepatotrophic viruses, including parvovirus B19 DNA". Yang SH, et al. Parvovirus B19 infection-related acute hepatitis after rituximab- containing regimen for treatment of diffuse large B-cell lymphoma. Annals of Hematology 91: 291-4, No. 2, Feb 2012 - Taiwan 803069830 1 Reactions 5 May 2012 No. 1400 0114-9954/10/1400-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1400 - 5 May 2012
SAntineoplastics
Parvovirus B19 infection-related acute hepatitis:case report
A 49-year-old woman was diagnosed with intestinaldiffuse large B-cell lymphoma. She received one cycle ofCEOP chemotherapy comprising cyclophosphamide,vincristine, epirubicin and dexamethasone, followed by fivecycles of CEOP with rituximab [routes and dosages notstated]. Following chemotherapy, she developed acutehepatitis with persistent leucopenia andthrombocytopenia.
Liver biopsy showed acute hepatitis, and parvovirus B19was found in some hepatocytes on immunohistochemistry.Parvovirus B19 infection was confirmed by PCR [durationof treatment to reaction onset not stated]. Eight monthsafter the onset of hepatitis, her liver function recoveredspontaneously.
Author comment: "For patients treated with rituximab-based regimens, we suggest a high degree of clinical suspicionfor hepatotrophic viruses, including parvovirus B19 DNA".Yang SH, et al. Parvovirus B19 infection-related acute hepatitis after rituximab-containing regimen for treatment of diffuse large B-cell lymphoma. Annals ofHematology 91: 291-4, No. 2, Feb 2012 - Taiwan 803069830
1
Reactions 5 May 2012 No. 14000114-9954/10/1400-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
