Antineoplastics
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Reactions 1325 - 30 Oct 2010 S Antineoplastics Cryptococcal lymphadenopathy: case report An 18-year-old woman developed cryptococcal lymphadenopathy during treatment with antineoplastics for acute lymphoblastic leukaemia [duration of treatment to reaction onset not stated]. During the woman’s induction chemotherapy consisting of vincristine, daunorubicin, asparaginase and prednisone [routes and dosages not stated], she developed neutropenia and fever. Imipenem and amikacin were initiated; she subsequently recovered and was in remission at the end of her induction phase. However, her fever returned with associated neutropenia and lymphopenia during her consolidation phase. Despite amikacin and imipenem therapy, she developed an isolated right subclavicular lymph node and her fever persisted. Crypotococci were identified by India ink test from a fine needle aspiration. Histology findings from her lymph node biopsy were suggestive of Cryptococcus neoformans and she was later diagnosed with cryptococcosis. The woman underwent surgical treatment and stated fluconazole. Two years later, she was in long-term remission and continued to have negative serum antigenic titres. Author comment: "Cryptococcal isolated lymph node is a rare complication in hematological malignancy. The diagnosis should be suggested every time a patient receiving chemotherapy and/or long course steroids, is developing an infectious lymphadenopathy." Harrabi H, et al. A probably isolated subclavicular lymphadenopathy in acute leukemia: An unusual localisation of cryptococcosis. Journal de Mycologie Medicale 20: 227-230, Sep 2010. Available from: URL: http://dx.doi.org/10.1016/ j.mycmed.2010.07.001 - Tunisia 803043070 1 Reactions 30 Oct 2010 No. 1325 0114-9954/10/1325-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1325 - 30 Oct 2010
SAntineoplastics
Cryptococcal lymphadenopathy: case reportAn 18-year-old woman developed cryptococcal
lymphadenopathy during treatment with antineoplasticsfor acute lymphoblastic leukaemia [duration of treatmentto reaction onset not stated].
During the woman’s induction chemotherapy consistingof vincristine, daunorubicin, asparaginase and prednisone[routes and dosages not stated], she developed neutropeniaand fever. Imipenem and amikacin were initiated; shesubsequently recovered and was in remission at the end ofher induction phase. However, her fever returned withassociated neutropenia and lymphopenia during herconsolidation phase. Despite amikacin and imipenemtherapy, she developed an isolated right subclavicularlymph node and her fever persisted. Crypotococci wereidentified by India ink test from a fine needle aspiration.Histology findings from her lymph node biopsy weresuggestive of Cryptococcus neoformans and she was laterdiagnosed with cryptococcosis.
The woman underwent surgical treatment and statedfluconazole. Two years later, she was in long-termremission and continued to have negative serum antigenictitres.
Author comment: "Cryptococcal isolated lymph node is arare complication in hematological malignancy. The diagnosisshould be suggested every time a patient receivingchemotherapy and/or long course steroids, is developing aninfectious lymphadenopathy."Harrabi H, et al. A probably isolated subclavicular lymphadenopathy in acuteleukemia: An unusual localisation of cryptococcosis. Journal de MycologieMedicale 20: 227-230, Sep 2010. Available from: URL: http://dx.doi.org/10.1016/j.mycmed.2010.07.001 - Tunisia 803043070
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Reactions 30 Oct 2010 No. 13250114-9954/10/1325-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
