Antineoplastics
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Reactions 1244 - 21 Mar 2009 Antineoplastics Nail discolouration in children: 2 case reports Two boys developed nail discolouration following antineoplastic therapy for acute lymphoblastic leukaemia (ALL) [dosages not stated]. About 6 weeks after commencing chemotherapy, an 8-year-old boy with relapsed ALL developed transverse hyperpigmented bands on his nails. The nail changes, which were present on the nail plates of all fingers and toes, appeared as single, transverse, 2mm bands of red discolouration across the breadth of the nail. At the time of symptom onset, he had completed 5 cycles of chemotherapy under the UK-ALL-R1 regimen, which comprised asparaginase, cyclophosphamide, cytarabine, daunorubicin, etoposide, methotrexate and vincristine. [Patient outcome and treatment not stated.] A 5-year-old boy with ALL developed Mee’s lines on the nail plates of all fingers and toes 4 weeks after completing 20 cycles of chemotherapy under the UK-ALL regimen. The nail changes appeared as single, transverse, 2mm bands of white discolouration across the breadth of the nail. He had received cytarabine, daunorubicin, etoposide, methotrexate and tioguanine. The nail changes were asymptomatic and moved distally as the nail grew, finally disappearing. Gupta A, et al. Chemotherapy induced nail changes. Indian Journal of Dermatology 53: 204-205, No. 4, 1 Oct 2008 - India 801132264 1 Reactions 21 Mar 2009 No. 1244 0114-9954/10/1244-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1244 - 21 Mar 2009
Antineoplastics
Nail discolouration in children: 2 case reportsTwo boys developed nail discolouration following
antineoplastic therapy for acute lymphoblastic leukaemia(ALL) [dosages not stated].
About 6 weeks after commencing chemotherapy, an8-year-old boy with relapsed ALL developed transversehyperpigmented bands on his nails. The nail changes,which were present on the nail plates of all fingers and toes,appeared as single, transverse, 2mm bands of reddiscolouration across the breadth of the nail. At the time ofsymptom onset, he had completed 5 cycles ofchemotherapy under the UK-ALL-R1 regimen, whichcomprised asparaginase, cyclophosphamide, cytarabine,daunorubicin, etoposide, methotrexate and vincristine.[Patient outcome and treatment not stated.]
A 5-year-old boy with ALL developed Mee’s lines on thenail plates of all fingers and toes 4 weeks after completing20 cycles of chemotherapy under the UK-ALL regimen. Thenail changes appeared as single, transverse, 2mm bands ofwhite discolouration across the breadth of the nail. He hadreceived cytarabine, daunorubicin, etoposide,methotrexate and tioguanine. The nail changes wereasymptomatic and moved distally as the nail grew, finallydisappearing.Gupta A, et al. Chemotherapy induced nail changes. Indian Journal ofDermatology 53: 204-205, No. 4, 1 Oct 2008 - India 801132264
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Reactions 21 Mar 2009 No. 12440114-9954/10/1244-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
