Antineoplastics
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Reactions 1298 - 24 Apr 2010 S Antineoplastics Stomatitis: case report A 53-year-old woman with multiple myeloma developed severe stomatitis following chemotherapy with vincristine, doxorubicin, dexamethasone and melphalan [time to reaction onset not stated]. The woman received cycles of vincristine, doxorubicin, dexamethasone chemotherapy [dosages and duration of therapy not stated], followed by bone marrow conditioning with melphalan 200 mg/m 2 [frequency and duration of treatment not stated] prior to autologous bone marrow transplantation (BMT). Five days prior to BMT (D-5), dental surgeons performed an examination of her oral mucosa, which was intact. From D-5 to D+2, she underwent preventive mucosal conditioning using laser treatment, but still developed grade 2 stomatitis on D+3. The woman received supportive therapy, which included topical corticsteroids and an antifungal mouthwash thrice daily, oral antiseptics, a lip moisturiser, artificial saliva and topical lidocaine before meals. Daily laser treatments continued, from which she derived significant pain relief. On D+5, her stomatitis worsened to grade 3. An ulcerated lesion on her upper lip was diagnosed as recurrent herpes labialis and another lesion at the back of her tongue was seen as pseudo-membranous candidiasis. By D+8, her stomatitis had progressed to grade 4, and she became unable to take food orally. She also developed renal failure which required two haemodialysis sessions. From D+35, her stomatitis gradually improved. A PCR assay on material taken from the one remaining lesion at the back of her tongue was negative for cytomegalovirus and herpes simplex virus. Forty-five days after BMT, her symptoms and oral lesions had completely resolved with no residual scarring. Pavesi VCS, et al. Rehabilitation of exacerbated case of oral mucositis associated with renal failure following bone marrow transplantation. Indian Journal of Dental Research 20: 365-9, No. 3, 2009 - Brazil 803010798 1 Reactions 24 Apr 2010 No. 1298 0114-9954/10/1298-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Antineoplastics
Reactions 1298 - 24 Apr 2010
SAntineoplastics
Stomatitis: case reportA 53-year-old woman with multiple myeloma developed
severe stomatitis following chemotherapy with vincristine,doxorubicin, dexamethasone and melphalan [time toreaction onset not stated].
The woman received cycles of vincristine, doxorubicin,dexamethasone chemotherapy [dosages and duration oftherapy not stated], followed by bone marrow conditioningwith melphalan 200 mg/m2 [frequency and duration oftreatment not stated] prior to autologous bone marrowtransplantation (BMT). Five days prior to BMT (D-5), dentalsurgeons performed an examination of her oral mucosa,which was intact. From D-5 to D+2, she underwentpreventive mucosal conditioning using laser treatment, butstill developed grade 2 stomatitis on D+3.
The woman received supportive therapy, which includedtopical corticsteroids and an antifungal mouthwash thricedaily, oral antiseptics, a lip moisturiser, artificial saliva andtopical lidocaine before meals. Daily laser treatmentscontinued, from which she derived significant pain relief.On D+5, her stomatitis worsened to grade 3. An ulceratedlesion on her upper lip was diagnosed as recurrent herpeslabialis and another lesion at the back of her tongue wasseen as pseudo-membranous candidiasis. By D+8, herstomatitis had progressed to grade 4, and she becameunable to take food orally. She also developed renal failurewhich required two haemodialysis sessions. From D+35,her stomatitis gradually improved. A PCR assay on materialtaken from the one remaining lesion at the back of hertongue was negative for cytomegalovirus and herpessimplex virus. Forty-five days after BMT, her symptoms andoral lesions had completely resolved with no residualscarring.Pavesi VCS, et al. Rehabilitation of exacerbated case of oral mucositis associatedwith renal failure following bone marrow transplantation. Indian Journal of DentalResearch 20: 365-9, No. 3, 2009 - Brazil 803010798
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Reactions 24 Apr 2010 No. 12980114-9954/10/1298-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
