Antineoplastics
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Reactions 1438 - 9 Feb 2013 S Antineoplastics Neutropenia, septic shock, and interstitial pneumonia in an elderly patient: case report A 65-year-old woman with squamous cell carcinoma of the breast developed neutropenia and septic shock during treatment with fluorouracil, epirubicin, and cyclophosphamide, and interstitial pneumonia during treatment with paclitaxel. The woman underwent a mastectomy and axillary lymph node dissection after diagnosis of breast cancer. She also had a history of dermatomyositis and was taking steroids [drugs not specified]. She received fluorouracil, epirubicin, and cyclophosphamide [routes and dosages not stated] as post- operative adjuvant chemotherapy. However, she discontinued this treatment after one course due to neutropenia, as well as septic shock and disseminated intravascular coagulation due to an infection of the inserted CV board. After recovery, her chemotherapy was changed to weekly paclitaxel [route and dose not stated]. However, she developed interstitial pneumonia after six courses of paclitaxel therapy and this was also discontinued. The woman made progress but after 1 month developed squamous cell carcinoma recurrence and went on to receive gimeracil/oteracil/tegafur [S-1]. She developed no metastasis or enlargement of the tumour and resection was performed. She also received radiotherapy. At last follow-up, she had no further recurrence and continued to visit hospital as an outpatient. Author comment: [T]he [fluorouracil, epirubicin, cyclophosphamide] therapy first selected was discontinued after one round, and then changed to weekly [paclitaxel] therapy. The [paclitaxel] therapy, however, also had adverse effects resulting in discontinuation. Kobayashi Y, et al. A resected case of complete response after treatment with S-1 for recurrent squamous cell carcinoma component of the breast. Gan to Kagaku Ryoho 39: 1403-1406, No. 9, Sep 2012 [Japanese; summarised from a translation] - Japan 803082742 1 Reactions 9 Feb 2013 No. 1438 0114-9954/10/1438-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Antineoplastics
Reactions 1438 - 9 Feb 2013
SAntineoplastics
Neutropenia, septic shock, and interstitialpneumonia in an elderly patient: case report
A 65-year-old woman with squamous cell carcinoma of thebreast developed neutropenia and septic shock duringtreatment with fluorouracil, epirubicin, andcyclophosphamide, and interstitial pneumonia duringtreatment with paclitaxel.
The woman underwent a mastectomy and axillary lymphnode dissection after diagnosis of breast cancer. She also had ahistory of dermatomyositis and was taking steroids [drugs notspecified]. She received fluorouracil, epirubicin, andcyclophosphamide [routes and dosages not stated] as post-operative adjuvant chemotherapy. However, she discontinuedthis treatment after one course due to neutropenia, as well asseptic shock and disseminated intravascular coagulation dueto an infection of the inserted CV board. After recovery, herchemotherapy was changed to weekly paclitaxel [route anddose not stated]. However, she developed interstitialpneumonia after six courses of paclitaxel therapy and this wasalso discontinued.
The woman made progress but after 1 month developedsquamous cell carcinoma recurrence and went on to receivegimeracil/oteracil/tegafur [S-1]. She developed no metastasisor enlargement of the tumour and resection was performed.She also received radiotherapy. At last follow-up, she had nofurther recurrence and continued to visit hospital as anoutpatient.
Author comment: [T]he [fluorouracil, epirubicin,cyclophosphamide] therapy first selected was discontinuedafter one round, and then changed to weekly [paclitaxel]therapy. The [paclitaxel] therapy, however, also had adverseeffects resulting in discontinuation.Kobayashi Y, et al. A resected case of complete response after treatment with S-1for recurrent squamous cell carcinoma component of the breast. Gan to KagakuRyoho 39: 1403-1406, No. 9, Sep 2012 [Japanese; summarised from a translation]- Japan 803082742
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Reactions 9 Feb 2013 No. 14380114-9954/10/1438-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
