Antineoplastics

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Reactions 1469, p6-7 - 14 Sep 2013 Antineoplastics Seizures and mucositis: case report A 28-year-old man developed seizures and mucositis during chemotherapy with paclitaxel, ifosfamide, carboplatin and etoposide [P-ICE; routes, dosages, durations of treatment to reactions onset and outcomes not stated]. The man was diagnosed with a poorly differentiated neuroendocrine tumour of the CNS. He received one cycle of standard-dose P-ICE, followed by four cycles of high-dose P- ICE. He subsequently developed mucositis and ifosfamide- induced seizures. Author comment: "Side effects comprised mucositis and ifosfamide induced seizures." Russel J, et al. High dose chemotherapy with autologous stem cell support induces sustainable complete remission of a poorly differentiated neuroendrocrine tumor of the CNS. Onkologie 35: 244, Oct 2012. Available from: URL: http:// dx.doi.org/10.1159/000178474 [abstract] - Germany 803092596 1 Reactions 14 Sep 2013 No. 1469 0114-9954/13/1469-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved

Transcript of Antineoplastics

Page 1: Antineoplastics

Reactions 1469, p6-7 - 14 Sep 2013

Antineoplastics

Seizures and mucositis: case reportA 28-year-old man developed seizures and mucositis during

chemotherapy with paclitaxel, ifosfamide, carboplatin andetoposide [P-ICE; routes, dosages, durations of treatment toreactions onset and outcomes not stated].

The man was diagnosed with a poorly differentiatedneuroendocrine tumour of the CNS. He received one cycle ofstandard-dose P-ICE, followed by four cycles of high-dose P-ICE. He subsequently developed mucositis and ifosfamide-induced seizures.

Author comment: "Side effects comprised mucositis andifosfamide induced seizures."Russel J, et al. High dose chemotherapy with autologous stem cell support inducessustainable complete remission of a poorly differentiated neuroendrocrine tumor ofthe CNS. Onkologie 35: 244, Oct 2012. Available from: URL: http://dx.doi.org/10.1159/000178474 [abstract] - Germany 803092596

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Reactions 14 Sep 2013 No. 14690114-9954/13/1469-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved