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ODK4M EROSION
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PP-g-GMA-CD
Dic
lofe
nac
o c
edid
o (
mg
/g)
0.0
0.5
1.0
1.5
PE-g-GMA-CD
Tiempo (horas)
0 4 8 12 16 20 24 60
0.0
0.5
1.0
2.0
4.0 8.0
5.414.0
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0 0,5000 1,000 1,500 2,000 2,500 3,000shear rate (1/s )
0
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visc
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Pa
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HPCS30D Steady state f low stepHPCL30D Steady state f low step
0,1000 1,000 10,00 100,0 1000ang. f requency (rad/s)
0,1000
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) 6 AA 1!& 6 (* & 1 AA
2 ' % " " $ *- " " * +" K' " ' " * S a "-
0,0
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40,0
60,0
80,0
100,0
0 250 500 750 1000 1250 1500
Tiempo (min.)
% T
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0 200 400 600 800 1000 1200 14000
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20
30
40
50
60
70
80
90
100
pH 6,8
% c
ipro
floxa
cion
libe
rado
tiempo (minutos)
100% Xantana 10 Ton 10 min con Ciprofloxacino (%) 50% Xantana y 50% Garrofina 10 Ton 10 min con Ciprofloxacino (%) 100% Xantana 7.5 Ton 10 min con Ciprofloxacino (%) 50% Xantana y 50% Garrofina 7.5 Ton 10 min con Ciprofloxacino (%)
pH 1,2
) $1+1/&+ >0 F#J / & 1 / 1+T0F"#! " * " * /-C * ' % Ja / "% *"%- 0 / / " " * * / - "% "" & , " " / @KJA +" " " *
2 * / % +" +" NJ# % " " ( * "- " , * (", %B@daA- +" ' "*, " / , -, "",$%'& '-% B "" *"+" *-#K' (Ja( -
0 100 200 300 400 500 600 700 800 900 10000
10
20
30
40
50
60
70
80
90
100
% c
ipro
floxa
cion
libe
rado
Tiempo (min)
50% Xantana y Garrofina con cubierta Eudragit L 100 50% Xantana y Garrofina sin cubierta
) D (/ &+ & F#J /@3> & * " , *" "$ '- " " "- " " C " , , $ */ Ka " Ja - 0 , " " *-.LgK3G1M KN@A M@NSA NKM@JMA MJ@SJA
$K3M MSM@SA J@NA KM@JMA K@KKJA
, , -
Ayunas
0
1
10
100
0 10 20 30 40 50 60Tiempo (h)
Lo
g C
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c (n
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Lovastatina SR
Altoprev
)61* A* + / 45F%
Dieta
0
1
10
100
0 10 20 30 40 50 60Tiempo (h)
Lo
g C
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)$1* A*+/ 45F%. " " " , , " " "-0 " " , " -!& " (* / A * + / &+
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0 20 40 60 80 100
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0
End
o
Temperature (C)
Raw PCL(1) Placebo PCL MS (2) Mixture 1:3 (3) Mixture 1:2 (4) Mixture 1:1 (5) Mixture 1.5:1 (6) Mixture 2:1 (7) Mixture 3:1 (8) Mixture 4:1 (9) Mixture 5:1 (10) Mixture 6:1 (11)(1)
(2)
0 20 40 60 80 100
-25
-20
-15
-10
-5
0
End
o
Temperature (C)
Raw PCL(1) Placebo PCL MS (2) Mixture 1:3 (3) Mixture 1:2 (4) Mixture 1:1 (5) Mixture 1.5:1 (6) Mixture 2:1 (7) Mixture 3:1 (8) Mixture 4:1 (9) Mixture 5:1 (10) Mixture 6:1 (11)(1)
(2)
Estudio de solubilidad CBD-PCL (DSC)
y = 0,1048x + 1,5341R2 = 0,9606
0
1
2
3
4
5
6
0,00 10,00 20,00 30,00 40,00 50,00
AH (J/g)
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TemperaturaC
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mV
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SUMAT
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DAP
EA
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30
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Temper atur a C
l iponegativoSUM Liponegat.blanco
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Lipoposi tSUM Lipopositblanco
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COMPOSICIN POR COMPRIMIDO (mg)
200 P 150 CM 100 CM 150 L 100 L 150 F 100 F
DICLOFENACO SDICO (DF) 100 100 100 100 100 100 100
PADAS (P) 200 150 100 150 100 150 100
CELULOSA MICROCRISTALINA (CM) --- 47 97 --- --- --- ---
LACTOSA (L) --- --- --- 47 97 --- ---
FOSFATO CLCICO (F) --- --- --- --- --- 47 97
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PARMETROS IN VITRO
200 P 150 CM 100 CM 150 L 100L 150 F 100 F
ABC in vitro 838,62 (122,09) 1471,75 (108,59)
1545,26 (244,58)
2188,09 (974,63)
2004,43 (217,66)
839,44 (97,31)
907,33 (126,68)
ED (%)
25,36 (4,44)
44,19 (3,05)
49,41 (9,79)
96,28 (53,64)
73,16 (9,17)
26,40 (3,18)
28,08 (3,64)
TMD (h)
8,96 (0,53)
6,70 (0,36)
6,07 (1,17)
0,45 (5,88)
3,22 (1,10)
8,83 (0,38)
8,63 (0,44)
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Teoras y Conceptos
Conocimientos prcticos
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Porcentaje de alumnos que respondi bastante o mucho.
Valora la importancia que se ha dado en tus estudios a los distintos mtodos utilizados
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