Reactions 739 - 20 Feb 1999

★ SBenazepril

First report of pancreatitis in an elderly patient:case report

A 70-year-old man with type 2 diabetes mellitus developedpancreatitis following treatment with benazepril for essentialhypertension.

Thirty minutes after taking his first dose of benazepril, theman experienced severe epigastric pain and cramping thatcontinued for 6–8 hours. The next day, he experienced thesame symptoms after taking his second dose, and the agentwas discontinued.

The man then experienced 2 episodes of vomiting and wasnot able to eat for 4 days. Approximately 1 week after the startof benazepril therapy, he decided to take a third dose of theagent (5mg) because of a high home BP reading. Once again,he experienced epigastric pain, nausea and vomiting.

The patient presented to an emergency department. Testsshowed sinus tachycardia and moderate epigastric tenderness.His serum amylase and lipase levels were 234 and 755 U/L,respectively. An abdominal CT scan showed a mildlyoedematous, inflamed pancreas and a single, non-obstructinggall stone.

The man was treated with bowel rest and pethidine[meperidine]. His pain improved over the following week andhe started to tolerate food. At the time of discharge, his serumamylase and lipase levels were 50 and 189 U/L, respectively.

Author comment: ‘Our patient clearly developedpancreatitis that was related to benazepril ingestion on threeseparate occasions.’Muchnick JS, et al. Angiotensin-converting enzyme inhibitor-induced pancreatitis.Clinical Cardiology 22: 50-51, Jan 1999 - USA 800740052

» Editorial comment: A search of AdisBase and Medline didnot reveal any case previous reports of pancreatitis associatedwith benazepril.

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Reactions 20 Feb 1999 No. 7390114-9954/10/0739-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved